Figure 3

Biomarkers of type II collagen turnover on day 7 and 22 corrected to baseline. A, B: Type II collagen degradation detected with C2M. Range of measurement was [0.3-1.2]. C, D: Type II degradation detected with CTX-II. Range of measurement was [0.2-2132.7]. E + F. Formation of type II collagen detected with P2NP. Range of measurement was [167.3-877.5]. G, H: Calculations of type II collagen turnover with C2M. Range of measurement was [0.0005-0.006]. I + J: Calculation of type II collagen turnover with CTX-II. Range of measurement was [0.3-72.0]. The CIA group (black, n = 10) and control animals (white, n = 10) were compared by Mann Whitney t-test. All statistical analyses were calculated based on baseline corrected values. Data are shown as mean ± SEM and significance levels as *: P < 0.05, **: P < 0.01, ***: P < 0.001.