Figure 2

Biomarkers of type I collagen turnover on day 7 and 22 corrected to baseline. A, B: Type I collagen degradation detected with C1M. Range of measurement was [55.4-116.7]. C, D: Formation of type I collagen detected with P1NP. Range of measurement was [398.0-8603.1]. E, F: Calculations of type I collagen turnover. Range of measurement was [0.009-0.1]. The CIA group (black, n = 10) and control animals (white, n = 10) were compared by Mann–Whitney t-test. All statistical analysis was calculated based on baseline corrected values. Data are shown as mean ± SEM and significance levels as *: P < 0.05, **: P < 0.01, ***: P < 0.001.