Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue

Table 1 Individual Cytokines as Illness Markers

Ranked Features PI-CFS vs Ctrl**			CC weight alpha=0
ROC		AUC-0.50	Wilcoxon	U statistic
IL-8	(pg/ml)	0.34	IL-5	0.31
IL-5	(pg/ml)	0.20	IL-23	0.30
IL-23	(pg/ml)	0.20	IL-8	0.24
IL-13	(pg/ml)	0.16	IFN-g	0.18
IL-2	(pg/ml)	0.16	TNFa	0.13
IL-15	(pg/ml)	0.14	TNFb	0.13
IL-17	(pg/ml)	0.13	IL-12p70	0.10
IL-6	(pg/ml)	0.10	IL-1b	0.07
IL-10	(pg/ml)	0.08	IL-1a	0.06
IFN-g	(pg/ml)	0.07	IL-13	0.06
IL-4	(pg/ml)	0.07	IL-2	0.06
TNFb	(pg/ml)	0.04	IL-15	0.04
IL-1a	(pg/ml)	0.04	IL-17	0.04
IL-1b	(pg/ml)	0.04	IL-4	0.03
TNFa	(pg/ml)	0.03	IL-10	0.03
IL-12p70	(pg/ml)	0.01	IL-6	0.00
Ranked Features PI-CFS vs Ctrl**			CC weight alpha=1.0
ROC		AUC-0.50	Wilcoxon	U statistic
IL-8	(pg/ml)	0.34	IL-5	0.31
IL-23	(pg/ml)	0.20	IL-8	0.24
IL-5	(pg/ml)	0.20	IL-23	0.30
IL-2	(pg/ml)	0.16	TNFb	0.13
IL-13	(pg/ml)	0.16	IFN-g	0.18
IL-6	(pg/ml)	0.10	TNFa	0.13
IL-17	(pg/ml)	0.13	IL-1a	0.06
IL-15	(pg/ml)	0.14	IL-12p70	0.10
IFN-g	(pg/ml)	0.07	IL-2	0.06
IL-10	(pg/ml)	0.08	IL-1b	0.07
IL-4	(pg/ml)	0.07	IL-13	0.06
IL-1a	(pg/ml)	0.04	IL-17	0.04
TNFb	(pg/ml)	0.04	IL-15	0.04
IL-1b	(pg/ml)	0.04	IL-10	0.03
TNFa	(pg/ml)	0.03	IL-4	0.03
IL-12p70	(pg/ml)	0.01	IL-6	0.00

Relative rank of individual cytokines based on their classification performance as evaluated by the area (AUC) under the receiver operating characteristic (ROC) curve and the Wilcoxon U statistic. Values without cross-correlation adjustment (CC Weight α=0) and with full cross-correlation adjustment are shown (CC weight α=1).
** Note: values were not log transformed since ROC rank is non-parametric.

ISSN: 1479-5876