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Table 1 Individual Cytokines as Illness Markers

From: Cytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue

Ranked Features PI-CFS vs Ctrl** CC weight alpha=0
ROC   AUC-0.50 Wilcoxon U statistic
IL-8 (pg/ml) 0.34 IL-5 0.31
IL-5 (pg/ml) 0.20 IL-23 0.30
IL-23 (pg/ml) 0.20 IL-8 0.24
IL-13 (pg/ml) 0.16 IFN-g 0.18
IL-2 (pg/ml) 0.16 TNFa 0.13
IL-15 (pg/ml) 0.14 TNFb 0.13
IL-17 (pg/ml) 0.13 IL-12p70 0.10
IL-6 (pg/ml) 0.10 IL-1b 0.07
IL-10 (pg/ml) 0.08 IL-1a 0.06
IFN-g (pg/ml) 0.07 IL-13 0.06
IL-4 (pg/ml) 0.07 IL-2 0.06
TNFb (pg/ml) 0.04 IL-15 0.04
IL-1a (pg/ml) 0.04 IL-17 0.04
IL-1b (pg/ml) 0.04 IL-4 0.03
TNFa (pg/ml) 0.03 IL-10 0.03
IL-12p70 (pg/ml) 0.01 IL-6 0.00
Ranked Features PI-CFS vs Ctrl** CC weight alpha=1.0
ROC   AUC-0.50 Wilcoxon U statistic
IL-8 (pg/ml) 0.34 IL-5 0.31
IL-23 (pg/ml) 0.20 IL-8 0.24
IL-5 (pg/ml) 0.20 IL-23 0.30
IL-2 (pg/ml) 0.16 TNFb 0.13
IL-13 (pg/ml) 0.16 IFN-g 0.18
IL-6 (pg/ml) 0.10 TNFa 0.13
IL-17 (pg/ml) 0.13 IL-1a 0.06
IL-15 (pg/ml) 0.14 IL-12p70 0.10
IFN-g (pg/ml) 0.07 IL-2 0.06
IL-10 (pg/ml) 0.08 IL-1b 0.07
IL-4 (pg/ml) 0.07 IL-13 0.06
IL-1a (pg/ml) 0.04 IL-17 0.04
TNFb (pg/ml) 0.04 IL-15 0.04
IL-1b (pg/ml) 0.04 IL-10 0.03
TNFa (pg/ml) 0.03 IL-4 0.03
IL-12p70 (pg/ml) 0.01 IL-6 0.00
  1. Relative rank of individual cytokines based on their classification performance as evaluated by the area (AUC) under the receiver operating characteristic (ROC) curve and the Wilcoxon U statistic. Values without cross-correlation adjustment (CC Weight α=0) and with full cross-correlation adjustment are shown (CC weight α=1).
  2. ** Note: values were not log transformed since ROC rank is non-parametric.