Figure 3
From: Development of a new humanized mouse model to study acute inflammatory arthritis
Histopathological changes in joints of humanized mice 7 days after the initiation of the CFA-induced arthritis. (A) H&E staining showing CFA-induced infiltration of the soft tissues of humanized mice treated with Etanercept (left) and PBS (right), magnification 20x. SL = synovial lining. Arrow denotes invasion site. (B) Histopathological scores for pannus formation, inflammation, and bone erosion in CFA-treated mice. (C) Immunohistochemistry for human CD45, human CD68, mouse CD45, and mouse F4/80 in humanized mice treated with PBS (upper row) and Etanercept (lower row). Magnification 40x. (D) Immunohistopathological scores for infiltration of human CD45+ cells, human CD68+ cells, mouse CD45+ cells, mouse F4/80+ cells, neutrophils, and lymphocytes in humanized mice treated with PBS or Etanercept. Data represents 5 (Etanercept) and 3 (PBS) mice/group.