Figure 5
From: Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis
Inhibition of CII-specific antibody production in arthritis mice following injections with IL-12 shRNA-transfected DC. Blood was taken 4 weeks after arthritis onset from experimental and control groups of mice treated with one (A) or two (B) injections of IL-12-silenced DC, as described in the legend to the Figure 2. Serum levels of anti-CII immunoglobulin Fc were determined using ELISA. Results show average levels of antibodies expressed as OD (n = 4 per group/experiment). * = P < 0.05 versus control shRNA-transfected DC.