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Table 2 The distribution of clinical and pathological parameters and the levels of miR-200c in blood

From: Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer

Parameter n miR-200c mean (SEM) p value High miR-200c n (%) p value
Age (y)    0.985   0.0895*
  < 70 32 100.3 (14.1)   17 (53.1%)  
  ≥70 20 112 (21.9)   11 (55%)  
Gender    0.692**   1***
  Male 42 107.3 (13.5)   23 (54.8%)  
  Female 10 94.2 (26.8)   5 (50%)  
Location    0.742**   1***
  Proximal, upper third 13 120.0 (31.1)   7 (53.8%)  
  Distal 36 98.5 (12.8)   19 (52.8%)  
  Multicentric 3 114.2 (58.3)   2 (66.7%)  
Stage    0.211   0.191*
  I-III 21 90.3 (17.4)   9 (42.9%)  
  IV 31 114.6 (16.3)   19 (61.3%)  
pT    0.683   0.693***
  pT1-T2 18 93.2 (31.6)   13 (72.2%)  
  pT3-T4 16 95.9 (17.6)   13 (81.3%)  
pN    0.516   0.259***
  Node Negative 9 67.4 (28.4)   3 (33.3%)  
  Node Positive 24 115.9 (18.6)   14 (58.3%)  
Histological type    0.179   0.246*
  Intestinal 28 86.5 (15.1)   13 (46.4%)  
  Diffuse 24 126.2 (18.5)   15 (62.5%)  
ECOG    0.263   0.481***
  0-1 37 94.2 (15.5)   20 (54.1%)  
  2 10 147.1 (56.2)   7 (70%)  
Residual disease (R)    0.113   0.312*
  R0 20 89.7 (18.2)   9 (4%)  
  R1-2 32 120.4 (27.9)   19 (59.4%)  
Number of Metastatic sites    0.551**   0.753***
  0 23 95.4 (16.5)   11 (47.8%)  
  1 21 113.2 (21.1)   12 (57.1%)  
   ≥2 8 109.8 (31.1)   5 (62.5%)  
Grade    0.405   0.146*
  Low 21 73.6 (20.9)   8 (38.1%)  
  High 27 116.9 (23.1)   16 (59.3%)  
Vascular / Perineural Invasion    0.914   0.705*
  No 11 103.3 (22.8)   5 (45.5%)  
  Yes 19 97.5 (22.8)   10 (52.6%)  
Neutrophils (10 -9 /L)    0.705   0.696*
  ≤ 7.5 39 104.4 (13.1)   22 (56.4%)  
  >7.5 12 114.9 (29.4)   6 (50%)  
  1. The miR-200c relative expression levels (REL) are shown in arbitrary units. The levels of miR-200c were considered high when the REL was above the mean. Residual disease (R) was categorised as R0 when no residual disease was present and as R1-2 when microscopic or macroscopic residual disease was found. Mann–Whitney test. * Pearson χ2. **Kruskal-Wallis test. *** Fisher's exact test.