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Table 2 The distribution of clinical and pathological parameters and the levels of miR-200c in blood

From: Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer

Parameter

n

miR-200c mean (SEM)

p value

High miR-200c n (%)

p value

Age (y)

  

0.985

 

0.0895*

   < 70

32

100.3 (14.1)

 

17 (53.1%)

 

   ≥70

20

112 (21.9)

 

11 (55%)

 

Gender

  

0.692**

 

1***

   Male

42

107.3 (13.5)

 

23 (54.8%)

 

   Female

10

94.2 (26.8)

 

5 (50%)

 

Location

  

0.742**

 

1***

   Proximal, upper third

13

120.0 (31.1)

 

7 (53.8%)

 

   Distal

36

98.5 (12.8)

 

19 (52.8%)

 

   Multicentric

3

114.2 (58.3)

 

2 (66.7%)

 

Stage

  

0.211

 

0.191*

   I-III

21

90.3 (17.4)

 

9 (42.9%)

 

   IV

31

114.6 (16.3)

 

19 (61.3%)

 

pT

  

0.683

 

0.693***

   pT1-T2

18

93.2 (31.6)

 

13 (72.2%)

 

   pT3-T4

16

95.9 (17.6)

 

13 (81.3%)

 

pN

  

0.516

 

0.259***

   Node Negative

9

67.4 (28.4)

 

3 (33.3%)

 

   Node Positive

24

115.9 (18.6)

 

14 (58.3%)

 

Histological type

  

0.179

 

0.246*

   Intestinal

28

86.5 (15.1)

 

13 (46.4%)

 

   Diffuse

24

126.2 (18.5)

 

15 (62.5%)

 

ECOG

  

0.263

 

0.481***

   0-1

37

94.2 (15.5)

 

20 (54.1%)

 

   2

10

147.1 (56.2)

 

7 (70%)

 

Residual disease (R)

  

0.113

 

0.312*

   R0

20

89.7 (18.2)

 

9 (4%)

 

   R1-2

32

120.4 (27.9)

 

19 (59.4%)

 

Number of Metastatic sites

  

0.551**

 

0.753***

   0

23

95.4 (16.5)

 

11 (47.8%)

 

   1

21

113.2 (21.1)

 

12 (57.1%)

 

   ≥2

8

109.8 (31.1)

 

5 (62.5%)

 

Grade

  

0.405

 

0.146*

   Low

21

73.6 (20.9)

 

8 (38.1%)

 

   High

27

116.9 (23.1)

 

16 (59.3%)

 

Vascular / Perineural Invasion

  

0.914

 

0.705*

   No

11

103.3 (22.8)

 

5 (45.5%)

 

   Yes

19

97.5 (22.8)

 

10 (52.6%)

 

Neutrophils (10 -9 /L)

  

0.705

 

0.696*

   ≤ 7.5

39

104.4 (13.1)

 

22 (56.4%)

 

   >7.5

12

114.9 (29.4)

 

6 (50%)

 
  1. The miR-200c relative expression levels (REL) are shown in arbitrary units. The levels of miR-200c were considered high when the REL was above the mean. Residual disease (R) was categorised as R0 when no residual disease was present and as R1-2 when microscopic or macroscopic residual disease was found. Mann–Whitney test. * Pearson χ2. **Kruskal-Wallis test. *** Fisher's exact test.