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Table 3 Univariate and multivariate analysis of the influence of genome-wide methylation profiles on OS of stage III CM patients

From: Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients

  

Univariate

Multivariate

Group1

# events/# patients2

HR3

95% CI

P

HR4

95% CI

P

LM

20/33

15

  

1

  

HM

12/12

3.30

1.56-6.99

0.001

2.41

1.02-5.70

0.045

LINE-1 hypomethylated

12/22

1

  

1

  

LINE-1 hypermethylated

20/23

2.52

1.21-5.26

0.01

1.76

0.75-4.13

0.20

  1. 1 Patients were divided by the k-means clustering algorithm in 2 groups (LM, HM), according to their genome-wide methylation profile, or by LINE-1 methylation being < (hypomethylated) or ≥ (hypermethylated) the median value of the population;
  2. 2 number of patients who died (# events) and total number of patients in the group (# patients) are reported.
  3. 3 Cox proportional hazard method was used to evaluate the effect of the examined variables on OS. Results were presented as Hazard Ratios (HR) with corresponding 95% Confidence Intervals (CI);
  4. 4 a multivariate Cox proportional hazard model was constructed for OS, including k-means clustering by whole-genome methylation profile and LINE-1 methylation;
  5. 5 set as reference.
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Journal of Translational Medicine

ISSN: 1479-5876

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