1 Patients were divided by the k-means clustering algorithm in 2 groups (LM, HM), according to their genome-wide methylation profile, or by LINE-1 methylation being < (hypomethylated) or ≥ (hypermethylated) the median value of the population;
2 number of patients who died (# events) and total number of patients in the group (# patients) are reported.
3 Cox proportional hazard method was used to evaluate the effect of the examined variables on OS. Results were presented as Hazard Ratios (HR) with corresponding 95% Confidence Intervals (CI);
4 a multivariate Cox proportional hazard model was constructed for OS, including k-means clustering by whole-genome methylation profile and LINE-1 methylation;