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Table 3 Univariate and multivariate analysis of the influence of genome-wide methylation profiles on OS of stage III CM patients

From: Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients

   Univariate Multivariate
Group1 # events/# patients2 HR3 95% CI P HR4 95% CI P
LM 20/33 15    1   
HM 12/12 3.30 1.56-6.99 0.001 2.41 1.02-5.70 0.045
LINE-1 hypomethylated 12/22 1    1   
LINE-1 hypermethylated 20/23 2.52 1.21-5.26 0.01 1.76 0.75-4.13 0.20
  1. 1 Patients were divided by the k-means clustering algorithm in 2 groups (LM, HM), according to their genome-wide methylation profile, or by LINE-1 methylation being < (hypomethylated) or ≥ (hypermethylated) the median value of the population;
  2. 2 number of patients who died (# events) and total number of patients in the group (# patients) are reported.
  3. 3 Cox proportional hazard method was used to evaluate the effect of the examined variables on OS. Results were presented as Hazard Ratios (HR) with corresponding 95% Confidence Intervals (CI);
  4. 4 a multivariate Cox proportional hazard model was constructed for OS, including k-means clustering by whole-genome methylation profile and LINE-1 methylation;
  5. 5 set as reference.