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Table 2 Characteristics of the 45 AJCC stage IIIC melanoma patients

From: Whole genome methylation profiles as independent markers of survival in stage IIIC melanoma patients

Variable n. patients %
Age, years   
  Median 52  
  Range 29-83  
Gender   
  Male 28 62.2
  Female 17 37.8
Localization of primary tumor   
  extremities 16 35.6
  trunk 24 53.3
  head & neck 2 4.4
  NA1 3 6.7
Breslow thickness of primary tumor   
  ≤2.0 mm 13 28.9
  >2.0 mm 25 55.6
  NA 7 15.6
Clark level of primary tumor   
  1-3 13 28.9
  4-5 26 57.8
  NA 6 13.3
Ulceration of primary tumor   
  No 10 22.2
  Yes 33 73.3
  NA 2 4.4
N. lymph nodes involved   
  1 9 20
  >1 35 77.8
  NA 1 2.2
LDH2   
  Low3 31 68.9
  High 11 24.4
  NA 3 6.7
BRAFV600E   
  mutated 25 55.6
  wild-type 15 33.3
  NA 5 11.1
LINE-1 4   
  hypomethylated 22 49
  hypermethylated 23 51
  1. 1 NA, not available.
  2. 2 LDH, lactate dehydrogenase.
  3. 3 low LDH is established as LDH values ≤ 0.8 times the upper limit of normal; high LDH is defined as LDH values > 0.8 times the upper limit of normal.
  4. 4 extent of methylation of LINE-1 was evaluated by pyrosequencing and defined as hypomethylated or hypermethylated depending on the methylation level being < or ≥ the median of the population, respectively.