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Table 1 Patient and tumour characteristics by histopathological subtypes

From: HLA-E expression in cervical adenocarcinomas: association with improved long-term survival

  SCC ASC AC P value
  n = 79 n = 38 n = 75  
Age (years), mean ± sd 49.8 ± 14.5 43.0 ± 11.7 44.7 ± 13.3 0.014
(95% CI for mean) (46.6-53.1) (39.1-46.8) (41.6-47.7)  
FIGO stage I, n (%) 64 (81) 34 (89) 67 (89) 0.260
FIGO stage II, n (%) 15 (19) 4 (11) 8 (11)  
High-risk HPV positive, n (%) 75 (95) 37 (97) 64 (85) 0.036
- HPV 16 51 (68) 19 (51) 28 (44) 0.003
- HPV 18 13 (17) 12 (32) 28 (44)  
- Other 11 (15) 6 (16) 8 (12)  
Tumour size ≥ 40 mm, n (%) 31 (41) 16 (42) 11 (16) 0.001
Infiltration depth ≥ 15 mm, n (%) 39 (51) 13 (34) 17 (24) 0.003
Positive LVSI, n (%) 47 (60) 19 (53) 23 (38) 0.037
Positive resection margins, n (%) 22 (28) 4 (11) 17 (23) 0.109
Positive parametria, n (%) 8 (10) 4 (11) 4 (5) 0.483
Positive lymph nodes, n (%) 27 (34) 9 (24) 15 (20) 0.125
Adjuvant radiotherapy, n (%) 48 (61) 18 (47) 30 (40) 0.034
Follow-up time (months), mean ± sd 199.4 ± 11.9 186.3 ± 16.6 201.9 ± 11.0 0.782
(95% CI for mean) (176.1-222.6) (153.9-218.8) (180.3-223.5)  
Recurrence-free time (months), mean ± sd 184.2 ± 12.4 168.3 ± 17.6 148.2 ± 10.5 0.977
(95% CI for mean) (160.0-208.4) (133.8-202.8) (127.5-168.8)  
Death, all causes, n (%) 34 (43) 12 (32) 22 (29) 0.177
Death by tumour, n (%) 19 (24) 10 (26) 16 (21) 0.828
Recurrent disease, n (%) 21 (27) 10 (26) 19 (24) 0.984
  1. P values were calculated using the Pearson Chi-square test for categorical data and one-way analysis of variance for numerical data. Total follow-up time and disease-free time were calculated by the Log Rank (Mantel-Cox) test for the histopathological subgroups separately. P values in bold type were considered statistically significant (P < 0.05). For nine, six, eighteen, and one cases the tumour size, depth of infiltration, LVSI (lymph-vascular space invasion), and tumour positivity of resection margins, respectively, could not be identified. SCC, cervical squamous cell carcinoma; ASC, cervical adenosquamous carcinoma; AC, cervical adenocarcinoma; FIGO, International Federation of Gynaecology and Obstetrics; HPV, human papillomavirus; CI, confidence interval.