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Figure 6 | Journal of Translational Medicine

Figure 6

From: TGF-β – an excellent servant but a bad master

Figure 6

TGF-β signaling in APL. Cytoplasmic isoform of PML (cPML) protein interacts with SMAD2/3 and SARA and is required for accumulation of SARA-SMAD2/3 and TGF-β receptors in early endosome. However, the PML-RARα oncoprotein physically interacts with cPML and thus leads to impaired TGF-β signaling

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