Figure 6From: TGF-β – an excellent servant but a bad masterTGF-β signaling in APL. Cytoplasmic isoform of PML (cPML) protein interacts with SMAD2/3 and SARA and is required for accumulation of SARA-SMAD2/3 and TGF-β receptors in early endosome. However, the PML-RARα oncoprotein physically interacts with cPML and thus leads to impaired TGF-β signalingBack to article page