Figure 5
The E2F1/miR-106b-25/p21 pathway. In gastric cancer, miR-106b-25 cluster is activated by E2F1 in parallel with its host gene, Mcm7. In turn, miR-106b and miR-93 regulate E2F1 expression, establishing a miRNA negative feedback loop. Over-expressed miR-106b, miR-93, and miR-25 inhibit the synthesis of p21CIP1 and Bim (TGF-β downstream effectors) and therefore prevent cell cycle inhibition and apoptosis