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Table 1 Patient and corresponding PDECX mouse model information

From: Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models

Patient information   Characterization & anti-tumor efficacy in the Patient-derived EC xenograft models
   HER-2 Mutation Trastuzumab efficacy
Gender/age Pathology TNM stage Grade Model ID FISH GCN FISH Ratio (HER-2/CEP17) IHC PIK3CA EGFR K-ras B-raf TGI% Tumor regression % P value
M/70 ESCC IIIB Moderate EC004 1.52 1.07 - - - - - 44 0 0.1333
M/61 ESCC IIA Poor EC016 2.38 1.25 - - - - - 0 0 0.3113
M/65 ESCC IIA Moderate EC039 3.92 1.26 ++ + - - - 41 0 0.2290
M/56 ESCC IIIA Moderate EC044 3.90 1.55 ++ - - - - >100 93 <0.0001
M/73 ESCC IIIA Moderate EC054 3.04 1.27 - - - - - 48 0 0.0004