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Table 1 Patient and corresponding PDECX mouse model information

From: Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models

Patient information

 

Characterization & anti-tumor efficacy in the Patient-derived EC xenograft models

  

HER-2

Mutation

Trastuzumab efficacy

Gender/age

Pathology

TNM stage

Grade

Model ID

FISH GCN

FISH Ratio (HER-2/CEP17)

IHC

PIK3CA

EGFR

K-ras

B-raf

TGI%

Tumor regression %

P value

M/70

ESCC

IIIB

Moderate

EC004

1.52

1.07

-

-

-

-

-

44

0

0.1333

M/61

ESCC

IIA

Poor

EC016

2.38

1.25

-

-

-

-

-

0

0

0.3113

M/65

ESCC

IIA

Moderate

EC039

3.92

1.26

++

+

-

-

-

41

0

0.2290

M/56

ESCC

IIIA

Moderate

EC044

3.90

1.55

++

-

-

-

-

>100

93

<0.0001

M/73

ESCC

IIIA

Moderate

EC054

3.04

1.27

-

-

-

-

-

48

0

0.0004