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Table 5 Univariate and multivariate analysis of TTT in Binet A patients below 70 year of age (n = 291, no missing cases)

From: IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

 

univariate

  

multivariate

  
    

initial model

final model

 

%

HR

p

HR

p

HR

p

age>65 years

22

0.96

0.85

-

   

male sex

56

1.01

0.97

-

   

ALC>14 × 109/L

42

1.35

0.0974

-

   

β2M>1 × ULN

38

2.04

<0.0001

1.53

0.0242

1.64

0.0069

CD38>30%

21

2.46

<0.0001

1.42

0.1042

-

 

ZAP-70>20%

36

2.72

<0.0001

1.39

0.1374

-

 

Unmutated IGHV

32

3.60

<0.0001

2.16

0.0012

3.09

<0.0001

del17p

7

2.59

0.0015

1.37

0.31

-

 

del11q

5

3.09

0.0005

2.21

0.02

1.97

0.0383

Year of diagnosis

  

0.85

-

   

   <2001

33

ref

     

   2001-2005

48

1.07

     

   >2005

19

0.89

     
  1. Final model obtained by stepwise backward elimination
  2. HR: hazard ratio
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Journal of Translational Medicine

ISSN: 1479-5876

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