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Table 4 Leave-one-out cross validation of the final model

From: IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

Step

covariate removed

no. of variables

log-l

AIC

cvlog-l

0

all (null model)

0

-675.7

-675.7

-846.8

1

none (final model)

6

-502.1

-509.1

-743.1

2

β2M

5

-504.6

-510.6

-738.8

3

β2M and sex

4

-618.9

-623.9

-738.8

  1. The final model included the following 6 variables: Binet stage, age > 65 years, unmutated IgVH, presence of del17p, male sex, β2 M > ULN
  2. Log-l: log-likelihood, AIC: Akaike's information criterion (AIC); cvlog-l: cross-validated log likelihood Removal of the least important variables (beta2M and sex) in step 2 and 3 resulted in a reduction of the fit by at least 2 criteria, demonstrating the validity of the model with 6 variables (according to reference #26)