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Table 3 Prognostic score for overall survival with clinical and biological risk factors and bootstrap validation

From: IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

 

final model1

  

variable selection2

 
 

β

HR

p

%

final score

Age>65 years

1.23

3.43

<0.0001

100

2

Binet B

1.02

2.77

<0.0001

92

2

Binet C

1.30

3.68

<0.0001

92

3

Gender (male)

0.59

1.80

0.0038

94

1

β2M >1 × ULN

0.46

1.59

0.0294

66

1

Del17p

0.72

2.06

0.0022

93

1

Unmutated IGHV

0.71

2.04

0.0003

98

1

calendar year

(in strata)

-

-

87

-

  1. HR: hazard ratio; β: Cox regression coefficient; ULN, upper limit of normal
  2. 1 Final model adjusted for year of diagnosis
  3. 2 Percentage of selection in 620 leave-one-out bootstrap samples. Percentages for del11, ZAP-70, CD38, LFN, ALC were respectively 28%, 21%, 15%, 24%, 46%