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Table 2 Univariate and multivariate Cox regression analysis for overall survival

From: IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

 

univariate

   

multivariate

   

initial model

final model

 

HR

p

HR

p

HR

p

age>65 years

2.99

<0.0001

3.53

<0.0001

3.43

<0.0001

male sex

1.86

0.0018

1.84

0.0030

1.80

0.0038

ALC>14 × 109/L

1.67

0.0062

1.34

0.17

-

 

β2M>1 × ULN

1.43

<0.0001

1.51

0.06

1.59

0.029

LNR ≥3

3.06

<0.0001

1.20

0.59

-

 

Binet stage

 

<0.0001

    

   A

ref

 

ref

 

ref

 

   B

3.20

 

2.19

0.0352

2.77

<0.0001

   C

4.95

 

2.86

0.0028

3.68

<0.0001

Rai stage

 

<0.0001

    

   0

ref

 

ND

   

   I-II

1.66

 

ND

   

   III-IV

5.08

 

ND

   

CD38>30%

1.73

0.0038

1.03

0.88

-

 

ZAP-70>20%

1.53

0.0204

1.04

0.83

-

 

Unmutated IGHV

2.46

<0.0001

2.04

0.0008

2.04

0.0003

del17p

3.44

<0.0001

2.14

0.0015

2.06

0.0022

del11q

1.39

0.248

ND

   

Year of diagnosis

 

0.0130

(in model as strata)*

(in model as strata)*

   <2001

ref

     

   2001-2005

1.46

     

   >2005

2.34

     

Therapy

 

0.106

ND

   

   Chemotherapy

ref

     

Immunochemotherapy

0.6

     
  1. Final model obtained by stepwise backward elimination
  2. HR: hazard ratio; ND: not done