| univariate |  |  |  | multivariate | |
---|---|---|---|---|---|---|
 |  |  | initial model | final model | ||
 | HR | p | HR | p | HR | p |
age>65 years | 2.99 | <0.0001 | 3.53 | <0.0001 | 3.43 | <0.0001 |
male sex | 1.86 | 0.0018 | 1.84 | 0.0030 | 1.80 | 0.0038 |
ALC>14 × 109/L | 1.67 | 0.0062 | 1.34 | 0.17 | - |  |
β2M>1 × ULN | 1.43 | <0.0001 | 1.51 | 0.06 | 1.59 | 0.029 |
LNR ≥3 | 3.06 | <0.0001 | 1.20 | 0.59 | - |  |
Binet stage | Â | <0.0001 | Â | Â | Â | Â |
   A | ref |  | ref |  | ref |  |
   B | 3.20 |  | 2.19 | 0.0352 | 2.77 | <0.0001 |
   C | 4.95 |  | 2.86 | 0.0028 | 3.68 | <0.0001 |
Rai stage | Â | <0.0001 | Â | Â | Â | Â |
   0 | ref |  | ND |  |  |  |
   I-II | 1.66 |  | ND |  |  |  |
   III-IV | 5.08 |  | ND |  |  |  |
CD38>30% | 1.73 | 0.0038 | 1.03 | 0.88 | - | Â |
ZAP-70>20% | 1.53 | 0.0204 | 1.04 | 0.83 | - | Â |
Unmutated IGHV | 2.46 | <0.0001 | 2.04 | 0.0008 | 2.04 | 0.0003 |
del17p | 3.44 | <0.0001 | 2.14 | 0.0015 | 2.06 | 0.0022 |
del11q | 1.39 | 0.248 | ND | Â | Â | Â |
Year of diagnosis | Â | 0.0130 | (in model as strata)* | (in model as strata)* | ||
   <2001 | ref |  |  |  |  |  |
   2001-2005 | 1.46 |  |  |  |  |  |
   >2005 | 2.34 |  |  |  |  |  |
Therapy | Â | 0.106 | ND | Â | Â | Â |
   Chemotherapy | ref |  |  |  |  |  |
Immunochemotherapy | 0.6 | Â | Â | Â | Â | Â |