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Table 1 Patients characteristics (n = 620)

From: IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia

median age, years (range)

65 (21-92)

median ALC, x109/L (range)

14 (2-460)

median β2M, xULN (range)

1.06 (0.13-11.9)

LNR ≥3

25%

Rai stage

 

   0

48%

   I-II

44%

   III-IV

8%

Binet stage

 

   A

70%

   B

22%

   C

8%

Male sex

60%

CD38 expression >30%

27%

ZAP-70 expression >20%

41%

Unmutated IgVH

41%

del11q-

9%

del17p-

10%

Year of diagnosis

 

   <=2000

29%

   2001-2005

49%

   >2005

22%

Treated

53%

median TTT, years

5.2

   Chemotherapy

28%

   Chemoimmunotherapy

15%

   missing data

10%

Dead

20%

median OS, years

15

  1. ALC, absolute lymphocyte count; LNR, number of lymph node involved regions; ULN, upper limit of normal; β2 M, beta-2 microglobulin, OS, overall survival; TTT, time to treatment. Complete data (n = 620) available for all variables, except for therapy