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Table 1 Distribution of mutations according to the characteristics of CRC patients

From: Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia

Characteristic

 

KRASmut

 

PI3Kmut

 

No. (N = 478)

 

No. (N = 384)

 

Sex

Male

293

84 (29%)

231

38* (16%)

Female

185

61 (33%)

153

29 (19%)

Tumor site

Right-transverse colon

172

54 (31%)

138

25* (18%)

Left colon

192

59 (31%)

151

23 (15%)

Rectum

114

32 (28%)

95

19 (20%)

Disease stage

Stage II

173

44 (25%)

143

22 (15%)

Stage III

160

56 (35%)

128

25 (20%)

Stage IV

145

45 (31%)

113

20* (18%)

Tumor grading

Well differentiated

56

17 (30%)

44

6 (14%)

Moderately differentiated

383

118 (31%)

309

54 (17%)

Poorly differentiated

39

10 (26%)

31

7* (23%)

Age, years

< 50

50

16 (32%)

45

5 (11%)

50-59

116

38 (33%)

102

14 (14%)

60-69

178

56 (31%)

151

30* (20%)

70+

134

35 (26%)

86

18 (21%)

  1. * 1 patient also mutated in BRAF.