Feature | CDKN2A N(%) | P-value | ||
---|---|---|---|---|
Negative (335; 79.4%) | Methylated (87; 20.6%) | |||
Age | Mean (range) | 69.3 (37–95) | 68.8 (39–89) | 0.7292 |
Tumor size | Mean (range) | 49.3 (5–160) | 53.5 (4–170) | 0.1265 |
Tumor location | Left-sided | 232 (69.5) | 40 (46.5) | <0.0001 |
Right-sided | 102 (30.5) | 46 (53.5) | ||
Gender | Female | 181 (54.0) | 48 (55.2) | 0.849 |
Male | 154 (46.0) | 39 (44.8) | ||
Histological subtype | Non-mucinous | 19 (5.7) | 11 (12.6) | 0.0209 |
Mucinous | 316 (94.3) | 76 (87.4) | ||
Tumor grade | G1-2 | 317 (96.7) | 74 (85.1) | <0.0001 |
G3 | 11 (3.4) | 13 (14.9) | ||
pT classification | pT1-2 | 75 (22.9) | 14 (16.1) | 0.1711 |
pT3-4 | 253 (77.1) | 73 (83.9) | ||
pN classification | pN0 | 180 (55.9) | 37 (43.0) | 0.0335 |
pN1-2 | 142 (44.1) | 49 (57.0) | ||
Vascular invasion | Absent | 238 (72.6) | 54 (62.1) | 0.0568 |
Present | 90 (27.4) | 33 (37.9) | ||
Invasive margin | Pushing | 101 (30.9) | 21 (24.4) | 0.242 |
Infiltrating | 226 (69.1) | 65 (75.6) | ||
Peritumoral lymphocytic inflammation | Absent | 251 (76.5) | 66 (75.9) | 0.897 |
Present | 77 (23.5) | 21 (24.1) | ||
KRAS (codon 12/13) | Wild-type | 227 (69.2) | 58 (72.5) | 0.565 |
Mutation | 101 (30.8) | 22 (27.5) | ||
BRAF (codon V600E) | Wild-type | 287 (94.1) | 53 (68.8) | <0.0001 |
Mutation | 18 (5.9) | 24 (31.2) | ||
MSI status | MSS/MSI-L | 272 (86.6) | 62 (76.5) | 0.0252 |
MSI-H | 42 (13.4) | 19 (23.5) |