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Table 2 Dose–response of Y27632 and blebbistatin

From: Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients

   

Y27632

blebbistatin

  

Untreated

10 μM

1 μM

0.1 μM

50 μM

5 μM

Central

Control (n = 6)

0,77

0,89 *

0,79

0,68

0,94 *

0,76

 

COPD (n = 3)

0,73

0,89

0,84

0,80

0,93

0,85

Distal

Control(n = 6)

0,72

0,82

0,70

0,70

0,91 **

0,71

 

COPD (n = 7)

0,51

0,87 **

0,55

0,59

0,93 ***

0,63

  1. Values show gel contraction after 24 hours compare to initial area at 0 hours.
  2. * p < 0.05 compared to untreated cells, ** p < 0.01 compared to untreated cells, *** p < 0.0001 compared to untreated cells.