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Table 2 Dose–response of Y27632 and blebbistatin

From: Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients

    Y27632 blebbistatin
   Untreated 10 μM 1 μM 0.1 μM 50 μM 5 μM
Central Control (n = 6) 0,77 0,89 * 0,79 0,68 0,94 * 0,76
  COPD (n = 3) 0,73 0,89 0,84 0,80 0,93 0,85
Distal Control(n = 6) 0,72 0,82 0,70 0,70 0,91 ** 0,71
  COPD (n = 7) 0,51 0,87 ** 0,55 0,59 0,93 *** 0,63
  1. Values show gel contraction after 24 hours compare to initial area at 0 hours.
  2. * p < 0.05 compared to untreated cells, ** p < 0.01 compared to untreated cells, *** p < 0.0001 compared to untreated cells.