a) IFN-γ ELIspot analyses | |||||||
---|---|---|---|---|---|---|---|
Patient ID | 1 | 2 | 3 | 6 | 7 | 11 | |
HLA-type | A2 | A2/A3 | A3, A11 | A2 | A2 | A1, A3 | |
A2 | Bcl-2WLD | NR | 43 | - | NR | 301 | - |
Bcl-xRIA | NR | 165 | - | NR | 197 | - | |
hTERTILA | 180 | 456 | - | 363 | 462 | - | |
CB9L2ALY | 232 | 135 | - | 293 | 441 | - | |
CB9 204ILI | 488 | 502 | - | 325 | 408 | - | |
NY-ESO 1SLL | 180 | 564 | - | 158 | 279 | - | |
MAGE A1KVL | NR | 57 | - | NR | 190 | - | |
MAGE A3FLW | 91 | 67 | - | 118 | 250 | - | |
SUR1M2LML | ND | 96 | - | ND | 349 | - | |
SUR9ELT | ND | 62 | - | ND | 274 | - | |
MART-1ELA | ND | 324* | - | 193* | NR | - | |
gp100ITD | ND | 106 | - | ND | ND | - | |
A3 | Bcl-xRIA | - | 284 | 111 | - | - | 59 |
SUR18K10RIS | - | ND | 112 | - | - | NR | |
SUR53DLA | - | 96 | ND | - | - | 82 | |
Rho C (nat)RAG | - | ND | 114 | - | - | NR | |
Rho C (mod)RLG | - | ND | 103 | - | - | NR | |
TAGRLS | - | ND | ND | - | - | 42* | |
Number of responses/total screened | 5/15 | 14/24 | 4/9 | 6/15 | 9/15 | 3/13 | |
Background | 99 | 46 | 86 | 130a/92b | 131 | 29 | |
b) MHC multimer staining | |||||||
Patient ID | 1 | 2 c | 3 | 6 | 7 | 11 d | |
HLA-type | A2 | A2, A3, B7 | A3, A11 | A2 | A2 | A1, A3 | |
A2 | MART-1ELA | 0.013 | 0.07* | - | 1.10* | 0.008 | - |
gp100YLE | 0.010 | NR | - | 10.0 | NR | - | |
gp100KTW | 0.010 | NR | - | NR | - | ||
gp100ITD | 0.002 | NR | - | 0.018 | NR | - | |
GnT-VVLP-9 | 0.015 | NR | - | NR | NR | - | |
A3 | TAGRLS | - | NR | NR | - | - | 0.60* |
Number of responses/total screened | 5/146 | 1/162 | 0/14 | 3/146 | 1/146 | 1/21 |