Figure 7

Enhanced replication of GLV-1h68 strain in CD44⁺CD24⁺ESA⁺cell population of GI-101A and in the tumors derived from CD44⁺CD24⁺ESA⁺cells. Enhanced replication of GLV-1h68 strain at (A) MOI0.01 and (B) MOI10 in CD44⁺CD24⁺ESA⁺ cell population of EMT induced GI-101A breast cancer cells followed by viral titration in CV-1 cells. (C) Enhanced fluorescent GFP protein expression in CD44⁺CD24⁺ESA⁺ cells derived tumor in comparison to CD44⁺CD24^-ESA⁺ cells. (D) Enhanced inhibition of tumor growth in CD44⁺CD24⁺ESA⁺ derived tumors in comparison to CD44⁺CD24^-ESA⁺ cells derived tumors.