Skip to main content

Table 3 Association analysis of genetic variation in TRAF6, MyD88,IRAK4 and IRAK1 between sepsis-induced ALI and sepsis alone patient

From: Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injury

Gene SNP Sepsis alone Sepsis-induced ALI Allelic Comparison Genotypic Comparison
P P adj OR (95% CI) ORadj(95% CI) P P adj
TRAF6 rs540386    0.24 0.42 0.69 (0.37–1.28) 0.72 (0.42–1.47) 0.23 0.42
CC 248 (90.8%) 250 (93.6%)       
TC 25 (9.2%) 17 (6.4%)       
C 521 (95.4%) 517 ( 96.8%)       
T 25 (4.6%) 17 (3.2%)       
rs4755453    0.00026 0.0012 0.52 (0.37–0.74) 0.71 (0.58–0.82) 0.00046 0.0021
GG 181 (66.5%) 215 (80.2%)       
CG 81 (29.8%) 51 (19%)       
CC 10 (3.7%) 2 (0.75%)       
G 446 (81.4%) 481 (89.7%)       
C 98 (18.6%) 55 (10.3%)       
rs5030493    0.23 0.36 0.78 (0.53–1.17) 0.69 (0.42–1.21) 0.15 0.24
AA 214 (79%) 218 (82%)       
TA 53 (19.6%) 48 (18%)       
TT 4 (1.5%) 0       
A 481 (88.8%) 484 (91%)       
T 61 (11.2%) 48 (9%)       
MyD88 rs6843    0.98 0.81 1.01 (0.50–2.04) 1.04 (0.62–2.12) 0.98 0.82
AA 256 (94.1%) 254 (94.1%)       
AG 16 (5.9%) 16 (5.9%)       
A 528 (97.1%) 524 (97%)       
G 16 (2.9%) 16 (3%)       
rs7744    0.73 0.75 1.04 (0.82–1.33) 1.03 (0.81–1.35) 0.91 0.92
AA 90 (33.3%) 87 (32.5%)       
AG 146 (54.1%) 144 (53.7%)       
GG 34 (12.6%) 37 (13.8%)       
A 326 (60.4%) 318 (59.3%)       
G 214 (39.6%) 218 (40.7%)       
IRAK4 rs3794262    0.38 0.65 1.16 (0.84–1.61) 1.02 (0.86–1.83) 0.33 0.46
  AA 198 (72.8%) 182 (68.2%)       
  TA 68 (25%) 81 (30.3%)       
  TT 6 (2.2%) 4 (1.5%)       
  A 464 (85.3%) 445 (83.3%)       
  T 80 (14.7%) 89 (16.7%)       
  rs4251429    0.37 0.58 1.26 (0.76–2.06) 1.13 (0.82–1.93) 0.26 0.52
  GG 242 (89.3%) 233 (86.3%)       
  GC 28 (10.3%) 37 (13.7%)       
  CC 1 (0.4%) 0       
  G 512 (94.5%) 503 (93.1%)       
  C 30 (5.5%) 37 (6.9%)       
  rs4251545    0.41 0.46 1.18 (0.79–1.77) 1.13 (0.65–1.67) 0.51 0.65
  GG 228 (83.5%) 215 (80.2%)       
  GA 41 (15%) 50 (18.7%)       
  AA 4 (1.5%) 3 (1.1%)       
  G 497 (91%) 480 (89.6%)       
  A 49 (9%) 56 (10.4%)       
  rs4251569    0.65 0.52 1.09 (0.76–1.56) 1.24 (0.79–2.01) 0.55 0.32
  CC 207 (77.2%) 200 (74.6%)       
  CT 56 (20.9%) 65 (24.3%)       
  TT 5 (1.9%) 3 (1.1%)       
  C 470 (87.7%) 465 (86.8%)       
  T 66 (12.3%) 71 (13.2%)       
  rs4251513    0.41 0.47 0.90 (0.70–1.15) 0.97 (0.82–1.26) 0.68 0.81
  CC 103 (37.7%) 111 (41.4%)       
  CG 128 (46.9%) 119 (44.4%)       
  GG 42 (15.4%) 38 (14.2%)       
  C 334 (61.2%) 341 (63.6%)       
  G 212 (38.8%) 195 (36.4%)       
  rs4251466    0.59 0.52 1.12 (0.74–1.69) 1.16 (0.82–1.75) 0.09 0.07
  CC 226 (84%) 216 (80.6%)       
  CT 38 (14.1%) 51 (19%)       
  TT 5 (1.9%) 1 (0.4%)       
  C 490 (91.1%) 483 (90.1%)       
  T 48 (8.9%) 53 (9.9%)       
  rs4251431    0.79 0.82 0.95 (0.63–1.43) 0.84 (0.76–1.32) 0.39 0.52
  GG 224 (82.7%) 221 (82.5%)       
  GT 43 (15.9%) 46 (17.2%)       
  TT 4 (1.5%) 1 (0.4%)       
  G 491 (90.6%) 488 (91%)       
  T 51 (9.4%) 48 (9%)       
  rs1461567    0.78 0.81 1.04 (0.81–1.32) 1.02 (0.92–1.25) 0.11 0.23
  CC 80 (29.4%) 88 (33%)       
  TC 136 (50%) 110 (41.2%)       
  TT 56 (20.6%) 69 (25.8%)       
  C 296 (54.4%) 286 (53.6%)       
  T 248 (45.6%) 248 (46.4%)       
IRAK1 rs1059703    0.26 0.73 0.70 (0.28–1.74)1 0.78 (0.38–1.69)
CC/C- 230 (84.6%) 220 (82.7%)       
CT 30 (11%) 38 (14.3%)       
  TT/T- 12 (4.4%) 8 (3%)       
  1. SNP, single nucleotide polymorphism; ALI, acute lung injury; OR, odds ratio; CI, confidence interval.
  2. Data were no. (%) of subjects. P was determined using the chi-square test. P adj and ORadj came from multivariate logistic regression.
  3. A P-value of < 0.0036 (0.05/14) was considered statistically significant after Bonferroni correction.
  4. 1 The p value was calculated using logistic regression method including sex as a covariate, in which males were coded as homozygote females.