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Table 3 Association analysis of genetic variation in TRAF6, MyD88,IRAK4 and IRAK1 between sepsis-induced ALI and sepsis alone patient

From: Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injury

Gene

SNP

Sepsis alone

Sepsis-induced ALI

Allelic Comparison

Genotypic Comparison

P

P adj

OR (95% CI)

ORadj(95% CI)

P

P adj

TRAF6

rs540386

  

0.24

0.42

0.69 (0.37–1.28)

0.72 (0.42–1.47)

0.23

0.42

CC

248 (90.8%)

250 (93.6%)

      

TC

25 (9.2%)

17 (6.4%)

      

C

521 (95.4%)

517 ( 96.8%)

      

T

25 (4.6%)

17 (3.2%)

      

rs4755453

  

0.00026

0.0012

0.52 (0.37–0.74)

0.71 (0.58–0.82)

0.00046

0.0021

GG

181 (66.5%)

215 (80.2%)

      

CG

81 (29.8%)

51 (19%)

      

CC

10 (3.7%)

2 (0.75%)

      

G

446 (81.4%)

481 (89.7%)

      

C

98 (18.6%)

55 (10.3%)

      

rs5030493

  

0.23

0.36

0.78 (0.53–1.17)

0.69 (0.42–1.21)

0.15

0.24

AA

214 (79%)

218 (82%)

      

TA

53 (19.6%)

48 (18%)

      

TT

4 (1.5%)

0

      

A

481 (88.8%)

484 (91%)

      

T

61 (11.2%)

48 (9%)

      

MyD88

rs6843

  

0.98

0.81

1.01 (0.50–2.04)

1.04 (0.62–2.12)

0.98

0.82

AA

256 (94.1%)

254 (94.1%)

      

AG

16 (5.9%)

16 (5.9%)

      

A

528 (97.1%)

524 (97%)

      

G

16 (2.9%)

16 (3%)

      

rs7744

  

0.73

0.75

1.04 (0.82–1.33)

1.03 (0.81–1.35)

0.91

0.92

AA

90 (33.3%)

87 (32.5%)

      

AG

146 (54.1%)

144 (53.7%)

      

GG

34 (12.6%)

37 (13.8%)

      

A

326 (60.4%)

318 (59.3%)

      

G

214 (39.6%)

218 (40.7%)

      

IRAK4

rs3794262

  

0.38

0.65

1.16 (0.84–1.61)

1.02 (0.86–1.83)

0.33

0.46

 

AA

198 (72.8%)

182 (68.2%)

      
 

TA

68 (25%)

81 (30.3%)

      
 

TT

6 (2.2%)

4 (1.5%)

      
 

A

464 (85.3%)

445 (83.3%)

      
 

T

80 (14.7%)

89 (16.7%)

      
 

rs4251429

  

0.37

0.58

1.26 (0.76–2.06)

1.13 (0.82–1.93)

0.26

0.52

 

GG

242 (89.3%)

233 (86.3%)

      
 

GC

28 (10.3%)

37 (13.7%)

      
 

CC

1 (0.4%)

0

      
 

G

512 (94.5%)

503 (93.1%)

      
 

C

30 (5.5%)

37 (6.9%)

      
 

rs4251545

  

0.41

0.46

1.18 (0.79–1.77)

1.13 (0.65–1.67)

0.51

0.65

 

GG

228 (83.5%)

215 (80.2%)

      
 

GA

41 (15%)

50 (18.7%)

      
 

AA

4 (1.5%)

3 (1.1%)

      
 

G

497 (91%)

480 (89.6%)

      
 

A

49 (9%)

56 (10.4%)

      
 

rs4251569

  

0.65

0.52

1.09 (0.76–1.56)

1.24 (0.79–2.01)

0.55

0.32

 

CC

207 (77.2%)

200 (74.6%)

      
 

CT

56 (20.9%)

65 (24.3%)

      
 

TT

5 (1.9%)

3 (1.1%)

      
 

C

470 (87.7%)

465 (86.8%)

      
 

T

66 (12.3%)

71 (13.2%)

      
 

rs4251513

  

0.41

0.47

0.90 (0.70–1.15)

0.97 (0.82–1.26)

0.68

0.81

 

CC

103 (37.7%)

111 (41.4%)

      
 

CG

128 (46.9%)

119 (44.4%)

      
 

GG

42 (15.4%)

38 (14.2%)

      
 

C

334 (61.2%)

341 (63.6%)

      
 

G

212 (38.8%)

195 (36.4%)

      
 

rs4251466

  

0.59

0.52

1.12 (0.74–1.69)

1.16 (0.82–1.75)

0.09

0.07

 

CC

226 (84%)

216 (80.6%)

      
 

CT

38 (14.1%)

51 (19%)

      
 

TT

5 (1.9%)

1 (0.4%)

      
 

C

490 (91.1%)

483 (90.1%)

      
 

T

48 (8.9%)

53 (9.9%)

      
 

rs4251431

  

0.79

0.82

0.95 (0.63–1.43)

0.84 (0.76–1.32)

0.39

0.52

 

GG

224 (82.7%)

221 (82.5%)

      
 

GT

43 (15.9%)

46 (17.2%)

      
 

TT

4 (1.5%)

1 (0.4%)

      
 

G

491 (90.6%)

488 (91%)

      
 

T

51 (9.4%)

48 (9%)

      
 

rs1461567

  

0.78

0.81

1.04 (0.81–1.32)

1.02 (0.92–1.25)

0.11

0.23

 

CC

80 (29.4%)

88 (33%)

      
 

TC

136 (50%)

110 (41.2%)

      
 

TT

56 (20.6%)

69 (25.8%)

      
 

C

296 (54.4%)

286 (53.6%)

      
 

T

248 (45.6%)

248 (46.4%)

      

IRAK1

rs1059703

  

0.26

0.73

0.70 (0.28–1.74)1

0.78 (0.38–1.69)

CC/C-

230 (84.6%)

220 (82.7%)

      

CT

30 (11%)

38 (14.3%)

      
 

TT/T-

12 (4.4%)

8 (3%)

      
  1. SNP, single nucleotide polymorphism; ALI, acute lung injury; OR, odds ratio; CI, confidence interval.
  2. Data were no. (%) of subjects. P was determined using the chi-square test. P adj and ORadj came from multivariate logistic regression.
  3. A P-value of < 0.0036 (0.05/14) was considered statistically significant after Bonferroni correction.
  4. 1 The p value was calculated using logistic regression method including sex as a covariate, in which males were coded as homozygote females.