Gene | SNP | Sepsis alone | Sepsis-induced ALI | Allelic Comparison | Genotypic Comparison | ||||
---|---|---|---|---|---|---|---|---|---|
P | P adj | OR (95% CI) | ORadj(95% CI) | P | P adj | ||||
TRAF6 | rs540386 |  |  | 0.24 | 0.42 | 0.69 (0.37–1.28) | 0.72 (0.42–1.47) | 0.23 | 0.42 |
CC | 248 (90.8%) | 250 (93.6%) | Â | Â | Â | Â | Â | Â | |
TC | 25 (9.2%) | 17 (6.4%) | Â | Â | Â | Â | Â | Â | |
C | 521 (95.4%) | 517 ( 96.8%) | Â | Â | Â | Â | Â | Â | |
T | 25 (4.6%) | 17 (3.2%) | Â | Â | Â | Â | Â | Â | |
rs4755453 |  |  | 0.00026 | 0.0012 | 0.52 (0.37–0.74) | 0.71 (0.58–0.82) | 0.00046 | 0.0021 | |
GG | 181 (66.5%) | 215 (80.2%) | Â | Â | Â | Â | Â | Â | |
CG | 81 (29.8%) | 51 (19%) | Â | Â | Â | Â | Â | Â | |
CC | 10 (3.7%) | 2 (0.75%) | Â | Â | Â | Â | Â | Â | |
G | 446 (81.4%) | 481 (89.7%) | Â | Â | Â | Â | Â | Â | |
C | 98 (18.6%) | 55 (10.3%) | Â | Â | Â | Â | Â | Â | |
rs5030493 |  |  | 0.23 | 0.36 | 0.78 (0.53–1.17) | 0.69 (0.42–1.21) | 0.15 | 0.24 | |
AA | 214 (79%) | 218 (82%) | Â | Â | Â | Â | Â | Â | |
TA | 53 (19.6%) | 48 (18%) | Â | Â | Â | Â | Â | Â | |
TT | 4 (1.5%) | 0 | Â | Â | Â | Â | Â | Â | |
A | 481 (88.8%) | 484 (91%) | Â | Â | Â | Â | Â | Â | |
T | 61 (11.2%) | 48 (9%) | Â | Â | Â | Â | Â | Â | |
MyD88 | rs6843 |  |  | 0.98 | 0.81 | 1.01 (0.50–2.04) | 1.04 (0.62–2.12) | 0.98 | 0.82 |
AA | 256 (94.1%) | 254 (94.1%) | Â | Â | Â | Â | Â | Â | |
AG | 16 (5.9%) | 16 (5.9%) | Â | Â | Â | Â | Â | Â | |
A | 528 (97.1%) | 524 (97%) | Â | Â | Â | Â | Â | Â | |
G | 16 (2.9%) | 16 (3%) | Â | Â | Â | Â | Â | Â | |
rs7744 |  |  | 0.73 | 0.75 | 1.04 (0.82–1.33) | 1.03 (0.81–1.35) | 0.91 | 0.92 | |
AA | 90 (33.3%) | 87 (32.5%) | Â | Â | Â | Â | Â | Â | |
AG | 146 (54.1%) | 144 (53.7%) | Â | Â | Â | Â | Â | Â | |
GG | 34 (12.6%) | 37 (13.8%) | Â | Â | Â | Â | Â | Â | |
A | 326 (60.4%) | 318 (59.3%) | Â | Â | Â | Â | Â | Â | |
G | 214 (39.6%) | 218 (40.7%) | Â | Â | Â | Â | Â | Â | |
IRAK4 | rs3794262 |  |  | 0.38 | 0.65 | 1.16 (0.84–1.61) | 1.02 (0.86–1.83) | 0.33 | 0.46 |
 | AA | 198 (72.8%) | 182 (68.2%) |  |  |  |  |  |  |
 | TA | 68 (25%) | 81 (30.3%) |  |  |  |  |  |  |
 | TT | 6 (2.2%) | 4 (1.5%) |  |  |  |  |  |  |
 | A | 464 (85.3%) | 445 (83.3%) |  |  |  |  |  |  |
 | T | 80 (14.7%) | 89 (16.7%) |  |  |  |  |  |  |
 | rs4251429 |  |  | 0.37 | 0.58 | 1.26 (0.76–2.06) | 1.13 (0.82–1.93) | 0.26 | 0.52 |
 | GG | 242 (89.3%) | 233 (86.3%) |  |  |  |  |  |  |
 | GC | 28 (10.3%) | 37 (13.7%) |  |  |  |  |  |  |
 | CC | 1 (0.4%) | 0 |  |  |  |  |  |  |
 | G | 512 (94.5%) | 503 (93.1%) |  |  |  |  |  |  |
 | C | 30 (5.5%) | 37 (6.9%) |  |  |  |  |  |  |
 | rs4251545 |  |  | 0.41 | 0.46 | 1.18 (0.79–1.77) | 1.13 (0.65–1.67) | 0.51 | 0.65 |
 | GG | 228 (83.5%) | 215 (80.2%) |  |  |  |  |  |  |
 | GA | 41 (15%) | 50 (18.7%) |  |  |  |  |  |  |
 | AA | 4 (1.5%) | 3 (1.1%) |  |  |  |  |  |  |
 | G | 497 (91%) | 480 (89.6%) |  |  |  |  |  |  |
 | A | 49 (9%) | 56 (10.4%) |  |  |  |  |  |  |
 | rs4251569 |  |  | 0.65 | 0.52 | 1.09 (0.76–1.56) | 1.24 (0.79–2.01) | 0.55 | 0.32 |
 | CC | 207 (77.2%) | 200 (74.6%) |  |  |  |  |  |  |
 | CT | 56 (20.9%) | 65 (24.3%) |  |  |  |  |  |  |
 | TT | 5 (1.9%) | 3 (1.1%) |  |  |  |  |  |  |
 | C | 470 (87.7%) | 465 (86.8%) |  |  |  |  |  |  |
 | T | 66 (12.3%) | 71 (13.2%) |  |  |  |  |  |  |
 | rs4251513 |  |  | 0.41 | 0.47 | 0.90 (0.70–1.15) | 0.97 (0.82–1.26) | 0.68 | 0.81 |
 | CC | 103 (37.7%) | 111 (41.4%) |  |  |  |  |  |  |
 | CG | 128 (46.9%) | 119 (44.4%) |  |  |  |  |  |  |
 | GG | 42 (15.4%) | 38 (14.2%) |  |  |  |  |  |  |
 | C | 334 (61.2%) | 341 (63.6%) |  |  |  |  |  |  |
 | G | 212 (38.8%) | 195 (36.4%) |  |  |  |  |  |  |
 | rs4251466 |  |  | 0.59 | 0.52 | 1.12 (0.74–1.69) | 1.16 (0.82–1.75) | 0.09 | 0.07 |
 | CC | 226 (84%) | 216 (80.6%) |  |  |  |  |  |  |
 | CT | 38 (14.1%) | 51 (19%) |  |  |  |  |  |  |
 | TT | 5 (1.9%) | 1 (0.4%) |  |  |  |  |  |  |
 | C | 490 (91.1%) | 483 (90.1%) |  |  |  |  |  |  |
 | T | 48 (8.9%) | 53 (9.9%) |  |  |  |  |  |  |
 | rs4251431 |  |  | 0.79 | 0.82 | 0.95 (0.63–1.43) | 0.84 (0.76–1.32) | 0.39 | 0.52 |
 | GG | 224 (82.7%) | 221 (82.5%) |  |  |  |  |  |  |
 | GT | 43 (15.9%) | 46 (17.2%) |  |  |  |  |  |  |
 | TT | 4 (1.5%) | 1 (0.4%) |  |  |  |  |  |  |
 | G | 491 (90.6%) | 488 (91%) |  |  |  |  |  |  |
 | T | 51 (9.4%) | 48 (9%) |  |  |  |  |  |  |
 | rs1461567 |  |  | 0.78 | 0.81 | 1.04 (0.81–1.32) | 1.02 (0.92–1.25) | 0.11 | 0.23 |
 | CC | 80 (29.4%) | 88 (33%) |  |  |  |  |  |  |
 | TC | 136 (50%) | 110 (41.2%) |  |  |  |  |  |  |
 | TT | 56 (20.6%) | 69 (25.8%) |  |  |  |  |  |  |
 | C | 296 (54.4%) | 286 (53.6%) |  |  |  |  |  |  |
 | T | 248 (45.6%) | 248 (46.4%) |  |  |  |  |  |  |
IRAK1 | rs1059703 |  |  | 0.26 | 0.73 | 0.70 (0.28–1.74)1 | 0.78 (0.38–1.69) | – | – |
CC/C- | 230 (84.6%) | 220 (82.7%) | Â | Â | Â | Â | Â | Â | |
CT | 30 (11%) | 38 (14.3%) | Â | Â | Â | Â | Â | Â | |
 | TT/T- | 12 (4.4%) | 8 (3%) |  |  |  |  |  |  |