The mRNA expressions of inflammatory and anti-inflammatory biomarkers in ischemic quadriceps by day 21 after CLI procedure (n = 8). A, B and C) indicating mRNA expressions of tumor necrotic factor (TNF-α), matrix metalloproteinase (MMP-9), and plasminogen activator inhibitor (PAI)-1, respectively.* vs. other groups with different symbols, p < 0.0004. D &E) showing mRNA expressions of interleukin (IL)-10 and endothelial nitric oxide (eNOS), respectively.* vs. other groups with different symbols, p < 0.009. Statistical analysis in each group by ANOVA followed by Bonferroni multiple comparison post hoc test. CLI = critical limb ischemia; Cil = cilostazol; Clo = clopidogrel.