Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression device, prehospital intraarrest cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized parallel groups comparative study proposal. “Prague OHCA study”

Table 2 Prague OHCA study inclusion and exclusion criteria

Inclusion criteria	Exclusion criteria
Age ≥18 and ≤ 65 years	OHCA of presumed non-cardiac cause
Wittnessed OHCA of presumed cardiac cause	Unwitnessed collapse
Minimum of 5 minutes of ACLS performed by emergency medical service team without sustained ROSC	Suspected or confirmed pregnancy
Unconsciousness¹	ROSC within 5 minutes of ACLS performed by EMS team
ECLS team and ICU bed capacity in cardiac center available	Conscious patient
	Known bleeding diathesis or suspected or confirmed acute or recent intracranial bleeding
	Suspected or confirmed acute stroke
	Known severe chronic organ dysfunction or other limitations in therapy
	“Do not resuscitate” order or other circumstances making 180 day survival unlikely
	Known pre-arrest cerebral performance category CPC ≥ 3

Abbreviations: OHCA: out-of hospital cardiac arrest; ACLS: advanced cardiac life support; ROSC: return of spontaneous circulation; ECLS: extracorporeal life support; ICU: intensive care unit; EMS: emergency medical service; CPC: cerebral performance category.
¹ defined as no response to verbal or painful stimuli during ACLS.

ISSN: 1479-5876