Figure 4From: Effects of sildenafil and/or muscle derived stem cells on myocardial infarctionIntracardiac implantation of MDSC improved the LVEF and reduced infarction size after LAD, but concurrent chronic sildenafil abrogated these effects. Intracardiac injection of saline or MDSC was conducted at 1 week (n = 7/group). Sildenafil was then given continuously in the drinking water until sacrifice at 4 weeks. Top: Ejection fraction before MI (basal), and at 1 and 4 weeks. NaCl: control injected with saline; MDSC: injection with MDSC; MDSC + S: MDSC with sildenafil. Bottom: quantitative image analysis of infarction area by Picrosirius red histochemistry. Statistical differences are stated for untreated versus basal, and MDSC, and MDSC + sildenafil versus untreated; *p < 0.05.Back to article page