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Table 5 The generation of multi-functional T cells in patients who responded to vaccination with DPX-0907

From: First-in-man application of a novel therapeutic cancer vaccine formulation with the capacity to induce multi-functional T cell responses in ovarian, breast and prostate cancer patients

Patient ID Indication Vaccine Dosage Antigen- specific Intracellular cytokine staining
    CD8+T cell population Multi-cytokine positivity Cytokines
      IFNγ TNFα IL-2
04-06a Breast 0.25 mL Total Double + + -
    Total Triple + + +
    TCM Double + + -
     Triple + + +
01-13a Breast 0.25 mL Total Double + + -
    TCM Double + + -
05-14 Ovarian 0.25 mL Total Double + + -
    Total Triple + + +
    TCM Double + + -
    TCM Triple + + +
03-17 Prostate 0.25 mL Total Double + + -
04-19 Breast 1.0 mL TCM Double + + -
    TCM Triple + + +
05-07 Ovarian 1.0 mL Total Double + + -
    TCM Double + + -
01-22a Ovarian 1.0 mL Total Double - + +
04-10 Prostate 1.0 mL Total Double + + -
    Total Double + - +
    Total Triple + + +
01-18a Prostate 1.0 mL Total Single + - -
    Total Single - + -
    Total Single - - +
    TCM Single + - -
  1. a These patients also showed the presence of IFN-γ secreting TEM cells.