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Table 5 The generation of multi-functional T cells in patients who responded to vaccination with DPX-0907

From: First-in-man application of a novel therapeutic cancer vaccine formulation with the capacity to induce multi-functional T cell responses in ovarian, breast and prostate cancer patients

Patient ID

Indication

Vaccine Dosage

Antigen- specific Intracellular cytokine staining

   

CD8+T cell population

Multi-cytokine positivity

Cytokines

     

IFNγ

TNFα

IL-2

04-06a

Breast

0.25 mL

Total

Double

+

+

-

   

Total

Triple

+

+

+

   

TCM

Double

+

+

-

    

Triple

+

+

+

01-13a

Breast

0.25 mL

Total

Double

+

+

-

   

TCM

Double

+

+

-

05-14

Ovarian

0.25 mL

Total

Double

+

+

-

   

Total

Triple

+

+

+

   

TCM

Double

+

+

-

   

TCM

Triple

+

+

+

03-17

Prostate

0.25 mL

Total

Double

+

+

-

04-19

Breast

1.0 mL

TCM

Double

+

+

-

   

TCM

Triple

+

+

+

05-07

Ovarian

1.0 mL

Total

Double

+

+

-

   

TCM

Double

+

+

-

01-22a

Ovarian

1.0 mL

Total

Double

-

+

+

04-10

Prostate

1.0 mL

Total

Double

+

+

-

   

Total

Double

+

-

+

   

Total

Triple

+

+

+

01-18a

Prostate

1.0 mL

Total

Single

+

-

-

   

Total

Single

-

+

-

   

Total

Single

-

-

+

   

TCM

Single

+

-

-

  1. a These patients also showed the presence of IFN-γ secreting TEM cells.