Synthetic genistein derivatives as modulators of glycosaminoglycan storage

Table 3 Effect of synthetic derivatives of genistein at 30 μM concentration on the number of different lysosomal structures in MPS IIIA and MPS IIIB fibroblasts

Compound	Number of structures per 100 μm²of cellular cross section ± SD
	lamellar	complexed	amorphous	total number
	MPS IIIA
None	0.40 ± 0.17	0.35 ± 0.35	0.38 ± 0.27	1.13 ± 0.50
IFG-032	0.14 ± 0.08 *	0.22 ± 0.11	0.17 ± 0.16 *	0.53 ± 0.19 *
IFG-034	0.17 ± 0.09 *	0.27 ± 0.14	0.17 ± 0.09 *	0.61 ± 0.20 *
IFG-036	0.19 ± 0.14 *	0.28 ± 0.16	0.22 ± 0.11	0.73 ± 0.31 *
IFG-038	0.32 ± 0.16	0.27 ± 0.13	0.21 ± 0.13	0.80 ± 0.24 *
IFG-066	0.13 ± 0.10 *	0.16 ± 0.08	0.18 ± 0.19 *	0.48 ± 0.17 *
IFG-071	0.28 ± 0.13	0.26 ± 0.09	0.25 ± 0.11	0.79 ± 0.22 *
IFG-072	0.20 ± 0.10 *	0.28 ± 0.10	0.34 ± 0.17	0.82 ± 0.23
	MPS IIIB
None	0.44 ± 0.18	0.14 ± 0.10	0.17 ± 0.12	0.75 ± 0.31
IFG-032	0.17 ± 0.11 *	0.10 ± 0.07	0.12 ± 0.08	0.40 ± 0.20 *
IFG-034	0.20 ± 0.16 *	0.06 ± 0.05	0.15 ± 0.08	0.41 ± 0.16 *
IFG-036	0.25 ± 0.21 *	0.12 ± 0.11	0.15 ± 0.18	0.50 ± 0.34
IFG-038	0.21 ± 0.12 *	0.10 ± 0.10	0.09 ± 0.09	0.41 ± 0.18 *
IFG-066	0.15 ± 0.10 *	0.11 ± 0.14	0.08 ± 0.06	0.34 ± 0.23 *
IFG-071	0.07 ± 0.07 *	0.07 ± 0.06	0.13 ± 0.09	0.26 ± 0.13 *
IFG-072	0.11 ± 0.12 *	0.16 ± 0.08	0.14 ± 0.10	0.41 ± 0.20 *

Asterisks (*) indicate statistically significant differences (one-way ANOVA with Tukey’s multiple comparisions as a post-hoc test, p < 0.05) relative to control MPS IIIA and MPS IIIB cells (None) where no tested compound was added into culture medium.

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