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Table 3 Effect of synthetic derivatives of genistein at 30 μM concentration on the number of different lysosomal structures in MPS IIIA and MPS IIIB fibroblasts

From: Synthetic genistein derivatives as modulators of glycosaminoglycan storage

Compound Number of structures per 100 μm2of cellular cross section ± SD
  lamellar complexed amorphous total number
  MPS IIIA
None 0.40 ± 0.17 0.35 ± 0.35 0.38 ± 0.27 1.13 ± 0.50
IFG-032 0.14 ± 0.08 * 0.22 ± 0.11 0.17 ± 0.16 * 0.53 ± 0.19 *
IFG-034 0.17 ± 0.09 * 0.27 ± 0.14 0.17 ± 0.09 * 0.61 ± 0.20 *
IFG-036 0.19 ± 0.14 * 0.28 ± 0.16 0.22 ± 0.11 0.73 ± 0.31 *
IFG-038 0.32 ± 0.16 0.27 ± 0.13 0.21 ± 0.13 0.80 ± 0.24 *
IFG-066 0.13 ± 0.10 * 0.16 ± 0.08 0.18 ± 0.19 * 0.48 ± 0.17 *
IFG-071 0.28 ± 0.13 0.26 ± 0.09 0.25 ± 0.11 0.79 ± 0.22 *
IFG-072 0.20 ± 0.10 * 0.28 ± 0.10 0.34 ± 0.17 0.82 ± 0.23
  MPS IIIB
None 0.44 ± 0.18 0.14 ± 0.10 0.17 ± 0.12 0.75 ± 0.31
IFG-032 0.17 ± 0.11 * 0.10 ± 0.07 0.12 ± 0.08 0.40 ± 0.20 *
IFG-034 0.20 ± 0.16 * 0.06 ± 0.05 0.15 ± 0.08 0.41 ± 0.16 *
IFG-036 0.25 ± 0.21 * 0.12 ± 0.11 0.15 ± 0.18 0.50 ± 0.34
IFG-038 0.21 ± 0.12 * 0.10 ± 0.10 0.09 ± 0.09 0.41 ± 0.18 *
IFG-066 0.15 ± 0.10 * 0.11 ± 0.14 0.08 ± 0.06 0.34 ± 0.23 *
IFG-071 0.07 ± 0.07 * 0.07 ± 0.06 0.13 ± 0.09 0.26 ± 0.13 *
IFG-072 0.11 ± 0.12 * 0.16 ± 0.08 0.14 ± 0.10 0.41 ± 0.20 *
  1. Asterisks (*) indicate statistically significant differences (one-way ANOVA with Tukey’s multiple comparisions as a post-hoc test, p < 0.05) relative to control MPS IIIA and MPS IIIB cells (None) where no tested compound was added into culture medium.