Figure 7
From: Specifically targeting ERK1 or ERK2 kills Melanoma cells
Silencing ERK1 and/or ERK2 increase sensitivity of A375 cells to killing by PLX4032. A. Relative killing percentages of A375 cells by PLX4032 (5 mM; 4 days) alone or when combined with indicated shRNAs. A375 cells were infected with shRNAs for a total of 4 days and PLX4032 added for the last 2 days. Note compared to either PLX4032 alone or the shRNAs alone, when combined there is increased killing (p < 0.001). Histograms represent the means +/- SEM based on 3 independent experiments. Statistical significance portrayed as follows: **p < 0.001.