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Figure 6 | Journal of Translational Medicine

Figure 6

From: Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice

Figure 6

The fibrotic and anti-fibrotic biomarkers (n = 8 for each group). A) & B) The protein expressions of transforming growth factor (TGF)-β and phosphorylated Smad3, two indicators of fibrosis, were significantly higher in obesity group than in control and obese-reduction groups, and notably higher in obese-reduction group than in control group. * vs. † vs. ‡, p<0.005. C) & D) The protein expressions of bone morphogenic protein (BMP)-2 and phosphorylated Smad1/5, two indices of anti-fibrosis, were remarkably lower in obesity than in control and obese-reduction groups, and significantly lower in obese-reduction group than in control group. * vs. † vs. ‡, p<0.001. All statistical analyses using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. Symbols (*, †, ‡) indicate significance (at 0.05 level) among A) to D).

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