Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

Table 1 Demographics of each group in the study, mean values and standard deviation

	CT-noCa	CT-plusCa	AMI	ANOVA
	n = 30	n = 30	n = 30	p-value
Age (yrs.)	60.2	60.3	64.5**	0.001
	[59.8; 60.7]	[60.0; 60.6]	[56.0; 73.0]
Triglycerides ^A (mmol/L)	1.57	1.49	1.30	0.52
	[0.85; 2.93]	[1.00; 2.21]	[0.78; 2.19]
HDL Cholesterol ^A (mmol/L)	1.28	1.36	1.13	0.07
	[0.93; 1.75]	[0.98; 1.89]	[0.83; 1.52]
LDL Cholesterol (mmol/L)	3.14	3.26	2.93	0.47
	[2.13; 4.16]	[2.29; 4.22]	[1.74; 4.11]
Total Cholesterol (mmol/L)	5.25	5.47	4.74	0.07
	[4.06; 6.43]	[4.29; 6.64]	[3.44; 6.04]
Systolic Blood Pressure (mm Hg)	145	147	159*	0.03
	[131; 159]	[128; 167]	[132; 187]
Diastolic Blood Pressure (mm Hg)	86	85	88	0.80
	[76; 95]	[75; 96]	[72; 103]
Agatston score	-	1299	-	-
		[717; 2352]
Heartscore ^A	5.29	6.38	8.00	0.07
	[2.89; 9.68]	[2.96; 13.7]	[4.01; 16.0]
Osteopontin ^A	83	99	111	0.08
	[52; 132]	[67; 145]	[61; 201]
Osteoprotegerin ^A	1583	1704	2170**	0.0007
	[1144; 2189]	[1335; 2175]	[1487; 3168]
Fibulin ^A	63	63	78**	0.0006
	[49; 80]	[50; 80]	[62; 99]

CT-noCa: Asymptomatic individuals without detectable coronary calcium; CT-plusCa: Asymptomatic CVD with high coronary calcium; AMI (Acute Myocardial Infarction): patients with NSTEMI-ACS. Mean values [+/− STD)], ^A Geometric mean values [+/− STD)], and p-value from one-way of analysis of variance (ANOVA). The level of significance of p-values from comparison of each group against the control group ‘CT-noCa‘was adjusted for multiple comparisons by the method of Dunnet (*: p < 0.05; **: p < 0.01; ***: p < 0.001).

ISSN: 1479-5876