Table 1 Focal ischemia models in spontaneously hypertensive
Author | Substrains | Age | BW (g) | MABP (mmHg) | Methods of MCAO | CBF | References |
|---|---|---|---|---|---|---|---|
Oyama N, et al. | SHR/Charles River Jpan | 10 wk | NA | 124±5 (SEM) | intraluminal suture | LDF | J Neurosci Res 2010;88:2889-2898 |
Zhao X, et al. | SHR/Harlan | NA | NA | NA | dMCAO+ipsi-CCAO (Brint) | LDF | Stroke 2010;41:363-367 |
Kranz A, et al. | SHR/Charles River | NA | 250 | NA | pMCAO (Tamura) | Â | Brain Res 2010;1315:128-136 |
Yang Y, et al. | SHR* | NA | 300-320 | NA | intraluminal suture | Â | J Neurochem 2010;112:134-149 |
Ito H, et al. | SHR/Hos, Japan SLC | 20-24 wk | 346±33 | 209±13 | photothrombotic dMCAO | LDF | J Cereb Blood Flow Metab 2010;30:343-351 |
Sun L, et al. | SHR/Janvier France | NA | 300-350 | 120±11 | blood clots embolism |  | J Cereb Blood Flow Metab 2010;30:1651-1660 |
Porritt MJ, et al. | SHR/ARC Australia | 16 mo | 438±11 | SBP=200-210 | intraluminal suture |  | J Cereb Blood Flow Metab 2010;30:1520-1526 |
Yao H, et al. | SHR/Izm, Japan SLC | 5-7 mo | 352±12 | 172±12 | photothrombotic dMCAO/Re | LDF | Neurochem Res 2009;34:1999-2007 |
Yao H, et al. | SHR/Izm, Japan SLC | 5-7 mo | NA | 182 (mean) | photothrombotic dMCAO/Re | LDF | J Cereb Blood Flow Metab 2009;29:565-574 |
McCabe C, et al. | SHRSP/Gla | 12-16 wk | 220-390 | 93±4 | intraluminal suture | MRI | Stroke 2009;40:3864-3868 |
Yan Y-P, et al. | SHR/Charles River USA | NA | 270-320 | NA | intraluminal suture | LDF | Neurochem Int 2009;55:826-832 |
Ashioti M, et al. | SHR/Charles River UK | NA | 200-250 | NA | dMCAO+ipsi-CCAO | Â | BMC Neurosci 2009;10:82 |
Ishikawa E, et al. | SHR/Kyushu | 5-8 mo | 360-440 | 154±11 | photothrombotic dMCAO | LDF | J Neurol Sci 2009;285:78-84 |
Omura-Matsuoka E, et al. | SHR/Charles River Jpan | 10-15 wk | 250-350 | 181±10 | intraluminal suture | LDF | Hypertens Res 2009;32:548-553 |
Cao F, et al. | SHRSP* | 13-15 wk | 250-300 | NA | dMCAO | Â | Brain Res 2009;1272:52-61 |
Liu Y-P, et al. | SHR/Charles River USA | NA | 290-310 | 130-140 | intraluminal suture | LDF | J Cereb Blood Flow Metab 2009;29:780-791 |
Sasaki T, et al. | SHR/Charles River Jpan | NA | 320±40 | NA | dMCAO+ipsi-CCAO (Brint) | LDF | Neurosci Lett 2009;449:61-65 |
Henning EC, et al. | SHR/Charles River USA | 3-4 mo | 350±20 | NA | intraluminal suture |  | J Cereb Blood Flow Metab 2009;29:1229-1239 |
Dharap A, et al. | SHR/Charles River USA | NA | 280-300 | NA | intraluminal suture | Â | J Cereb Blood Flow Metab 2009;29:675-687 |
Ishibashi S, et al. | SHR/Charles River USA | 8 wk | 180-220 | NA | dMCAO | Â | J Cereb Blood Flow Metab 2009;29:606-620 |
Yamashita T, et al. | SHR/Izm, Japan SLC | 13 wk | 250-280 | 117±29 | intraluminal suture | LDF | J Cereb Blood Flow Metab 2009;29:715-725 |
Fujiwara N, et al. | SHR/Charles River USA | NA | 303±8 | 183±6 | blood clots embolism | LDF | BMC Neurosci 2009;10:79 |
Murata Y, et al. | SHR/Charles River USA | NA | 283±8 | 184±5 | blood clots embolism | LDF | Stroke 2008;39:3372-3377 |
Matsuzaki T, et al. | SHR/Izm, Japan SLC | 9 wk | 240-290 | 126±17 | intraluminal suture | LDF | Neurol Res 2008;30:531-535 |
Kozak W, et al. | SHR/Charles River USA | 12-13 wk | 275-300 | 135±8 (telemetry) | intraluminal suture | LDF | J Pharmacol Exp Ther 2008;326:773-782 |
Henning EC, et al. | SHR/Charles River USA | 3-4 mo | 300-360 | SBP=165-185 | intraluminal suture | Â | Stroke 2008;39:3405-3410 |
Park S-W, et al. | SHR/Charles River USA | NA | 250-350 | NA | intraluminal suture | LDF | J Neurosurg 2007;107:593-599 |
Korde AS, et al. | SHR/Harlan | NA | 250-350 | 94±3 | dMCAO+ipsi-CCAO (Brint) | LDF | J Neurotrauma 2007;24:895-908 |
Kurasako T, et al. | SHR/Harlan | NA | 220-300 | 101±12 | dMCAO+ipsi-CCAO (Brint) |  | J Cereb Blood Flow Metab 2007;27:1919-1930 |
Jimenez-Altayo F, et al. | SHR/Janvier Spain | 13-15 wk | 341±4 (SEM) | SBP=204±2 (SEM) | intraluminal suture |  | Am J Physiol Heart Circ Physiol 2007;293:H628-635 |
Tureyen K, et al. | SHR/Charles River USA | NA | NA | 135±9 | intraluminal suture | LDF | J Neurochem 2007;101:41-56 |
Yao H, et al. | SHRSP/Izm, Japan SLC | 5 mo | 315±30 | 241±22 | photothrombotic dMCAO | LDF | Physiol Genomics 2007;30:69-73 |
Ashioti M, et al. | SHR/Charles River UK | NA | 265±9 | NA | dMCAO+ipsi-CCAO |  | Brain Res 2007;1145:177-189 |
Mariucci G, et al. | SHR/Charles River Italy | 12-14 wk | 250-330 | NA | pMCAO (Tamura) | Â | Neurosci Lett 2007;415:77-80 |
Adibhatla RM, et al. | SHR/Charles River USA | NA | 250-300 | NA | intraluminal suture | Â | Brain Res 2007;1134:199-205 |
Leker RR, et al. | SHR/Tel Aviv | NA | NA | NA | dMCAO | Â | Stroke 2007;38:153-161 |
Kumai Y, et al. | SHR/Kyushu | 5-8 mo | 340-435 | 164±2 (SEM) | photothrombotic dMCAO | LDF | J Cereb Blood Flow Metab 2007;27:1152-1160 |
Yang Y, et al. | SHR* | NA | 300-320 | NA | intraluminal suture | Â | J Cereb Blood Flow Metab 2007;27:697-709 |
Yan Y-P, et al. | SHR/Charles River USA | NA | 270-300 | NA | intraluminal suture | LDF | J Cereb Blood Flow Metab 2007;27:1213-1224 |
Takasawa M, et al. | SHR/Charles River UK | NA | 295-305 | NA | dMCAO+ipsi-CCAO | Â | J Cereb Blood Flow Metab 2007;27:679-689 |
Akaiwa K, et al. | SHR* | NA | 250-290 | 144±5 | intraluminal suture | LDF | Brain Res 2006;1122:47-55 |
Yan Y-P, et al. | SHR/Charles River USA | NA | 250-300 | 130-140 | intraluminal suture | LDF | Eur J Neurosci 2006;24:45-54 |
Lammer A, et al. | SHR/Charles River Germany | NA | 250-300 | NA | pMCAO (Tamura) | Â | Eur J Neurosci 2006;23:2824-2828 |
Bowen KK, et al. | SHR/Charles River USA | NA | 280-320 | NA | intraluminal suture | LDF | Neurochem Int 2006;49:127-135 |
Komitova M, et al. | SHR/Mollegaard | 6 mo | NA | NA | dMCAO | Â | Exp Neurol 2006;199:113-121 |
Zhao L, et al. | SHR/Charles River USA | NA | 250-350 | 118±12 | dMCAO+ipsi-CCAO (Brint) | AR / LDF | J Cereb Blood Flow Metab 2006;26:1128-1140 |
Zhang B, et al. | SHRSP* | 16-18 wk | NA | 204±7 | dMCAO |  | J Cereb Blood Flow Metab 2006;26:708-721 |
Furuya K, et al. | SHR/Charles River Jpan | NA | 280-320 | NA | dMCAO+ipsi-CCAO (Brint) | LDF | J Neurosurg 2005;103:715-723 |
Kamiya T, et al. | SHR/Harlan | NA | 225-325 | 161±13 | dMCAO+ipsi-CCAO (Brint) | AR | Stroke 2005;36:2463-2467 |
Naylor M, et al. | SHR/Charles River USA | NA | 280-320 | NA | intraluminal suture | LDF | Neurochem Int 2005;47:565-572 |
Adibhatla RM, et al. | SHR* | NA | 250-275 | NA | intraluminal suture | LDF | Brain Res 2005;1058:193-197 |
Tsuji K, et al. | SHR* | NA | 260-280 | NA | intraluminal suture | LDF | Stroke 2005;36:1954-1959 |
Gunther A, et al. | SHR/Charles River Germany | NA | 250-330 | NA | pMCAO (Tamura) | Â | Eur J Neurosci 2005;21:3189-3194 |
Vemuganti R | SHR/Charles River USA | NA | 280-320 | NA | intraluminal suture | LDF | Neurochem Int 2005;47:136-142 |
Komitova M, et al. | SHR/Mollegaard | 6 mo | 300-370 | NA | dMCAO | Â | Eur J Neurosci 2005;21:2397-2405 |
Onoue S, et al. | SHRSP* | NA | 280-320 | NA | dMCAO+ipsi-CCAO (Brint) | Â | Brain Res Mol Brain Res 2005;134:189-197 |
Hobohm C, et al. | SHR/Charles River Germany | NA | 250-330 | NA | pMCAO (Tamura) | Â | J Neurosci Res 2005;80:539-548 |
Drummond JC, et al. | SHR/Harlan | 16-20 wk | 375-425 | 131±9 | intraluminal suture |  | Anesth Analg 2005;100:841-846 |
Ooboshi H, et al. | SHR/Kyushu | 5-8 mo | 340-430 | NA | photothrombotic dMCAO | LDF | Circulation 2005;111:913-919 |
Takada J, et al. | SHR/Kyushu | 7-8 mo | 352-450 | 153±10 | photothrombotic dMCAO | LDF | Gene Ther 2005;12:487-493 |
Kumai Y, et al. | SHR/Kyushu | 5-10 mo | 320-400 | 181±21 | photothrombotic dMCAO | LDF | J Cereb Blood Flow Metab 2004;24:1359-1368 |
Carswell HV, et al. | SHRSP/Gla, female | 3-4 mo | 179±11 | 140±15 | dMCAO |  | J Cereb Blood Flow Metab 2004;24:298-304 |
Franke H, et al. | SHR/Charles River Germany | NA | 250-330 | NA | pMCAO (Tamura) | Â | J Neuropathol Exp Neurol 2004;63:686-699 |
Zhang B, et al. | SHRSP* | 12-13 wk | 250-300 | NA | dMCAO | Â | Neuroscience 2004;126:433-440 |
Dhodda VK, et al. | SHR/Charles River USA | NA | 280-320 | NA | intraluminal suture | LDF | J Neurochem 2004;89:73-89 |
Nurmi A, et al. | SHR/M&B A/S | NA | NA | NA | pMCAO | Â | Stroke 2004;35:987-991 |
Vemuganti R, et al. | SHR/Charles River USA | NA | 280-320 | 124±11 | intraluminal suture | LDF | Stroke 2004;35:179-184 |
Ren Y, et al. | SHR/Harlan | NA | 250-300 | 124±16 | dMCAO+ipsi-CCAO (Brint) |  | J Cereb Blood Flow Metab 2004;24:42-53 |
Kumai Y, et al. | SHR/Kyushu, female | 5-7 mo | 195-240 | 170±2 (SEM) | photothrombotic dMCAO | LDF | Exp Neurol 2003;184:904-911 |
Babu GN, et al. | SHR* | NA | 250-300 | NA | intraluminal suture | LDF | Neurochem Res 2003;28:1851-1857 |
Gautier S, et al. | SHR/Elevage Janvier France | NA | 270-320 | NA | intraluminal suture | Â | Stroke 2003;34:2975-2979 |
Asahi M, et al. | SHR/Taconic Farms | NA | NA | NA | blood clots embolism | LDF | J Cereb Blood Flow Metab 2003;23:895–899. |
Teichner A, et al. | SHR* | 13 wk | NA | NA | dMCAO | Â | Exp Neurol 2003;182:353-360 |
Sadanaga-Akiyoshi F, et al. | SHR/Kyushu | 5-7 mo | 315-425 | 178±11/176±7 | photothrombotic dMCAO | LDF | Neurochem Res 2003;28:1227-1234 |
Dahlqvist P, et al. | SHR/Mollegaard | 14-15 wk | NA | NA | dMCAO | Â | Neuroscience 2003;119:643-652 |
Pettigrew LC, et al. | SHR/Harlan | NA | 250-300 | 98±17 | dMCAO+ipsi-CCAO (Brint) |  | Neurol Res 2003;25:201-207 |
Yan Y, et al. | SHR/Charles River USA | NA | 270-310 | 133±9 | intraluminal suture |  | Brain Res 2003;961:22-31 |
Yamakawa H, et al. | SHR/Taconic Farms | 12 wk | 300-500 | SBP=156±4 | dMCAO |  | J Cereb Blood Flow Metab 2003;23:371-380 |
Wiessner C, et al. | SHR/Iffa Credo | NA | 220-300 | NA | dMCAO | Â | J Cereb Blood Flow Metab 2003;23:154-165 |
Rao VLR, et al. | SHR/Charles River USA | NA | 280-320 | NA | intraluminal suture | LDF | J Neurochem 2002;83:1072-1086 |
Aoki T, et al. | SHR* | NA | NA | 177±6 | blood clots embolism | LDF | Stroke 2002;33:2711-2717 |
Leker RR, et al. | SHR/Tel Aviv | 13 wk | NA | 127±11 | dMCAO | LDF | Exp Neurol 2002;176:355-363 |
Leker RR, et al. | SHR/Tel Aviv | 13 wk | NA | 127±5 | dMCAO | LDF | Stroke 2002;33:1085-1092 |
Adibhatla RM, et al. | SHR* | NA | NA | NA | intraluminal suture | Â | Brain Res 2002;938:81-86 |
Sakakibara Y, et al. | SHR/Charles River USA | NA | 280-350 | 116-128 | intraluminal suture | Â | Brain Res 2002;931:68-73 |
Sumii T, et al. | SHR/Taconic Farms | NA | NA | 185±6 (SEM) | blood clots embolism | LDF | Stroke 2002;33:831-836 |
Jin J, et al. | SHR/Hos, Japan SLC | NA | 130-160 | NA | pMCAO | AR | Pharmacology 2002;64:119-125 |
Higuchi T, et al. | SHR/Charles River Jpan | NA | 261±32 | 88±12 | dMCAO+ipsi-CCAO (Brint) | LDF | J Cereb Blood Flow Metab 2002;22:71-79 |
Ito T, et al. | SHR/Taconic Farms | 8 wk | 190-240 | SBP=153±6 (SEM) | dMCAO |  | Stroke 2002;33:2297-2303 |
Wallace JA, et al. | SHR* | NA | 280-320 | NA | intraluminal suture | Â | J Cereb Blood Flow Metab 2002;22:1303-1310 |
Komitova M, et al. | SHR/Mollegaard | NA | NA | NA | dMCAO | Â | J Cereb Blood Flow Metab 2002;22:852-860 |
Johanson BB, et al. | SHR/Mollegaard | 3 mo | NA | NA | dMCAO | Â | J Cereb Blood Flow Metab 2002;22:89-96 |
Dijkhuizen RM, et al. | SHR/Taconic Farms | NA | 300-350 | NA | blood clots embolism | MRI | Stroke 2002;33:2100-2104 |
Yao H, et al. | SHR/Kyushu | 5-7 mo | 346-444 | 196 (mean) | photothrombotic dMCAO/Re | LDF | Neuroreport 2002;13:1005-1008 |
Kitayama J, et al. | SHR/Kyushu | 5-8 mo | 305-438 | 161±5 (SEM) | photothrombotic dMCAO | LDF | Brain Res 2001;922:223-228 |
Furuya K, et al. | SHR* | NA | NA | NA | dMCAO+ipsi-CCAO (Brint) | Â | Stroke 2001;32:2665-2674 |
Takagi K, et al. | SHR/Funabashi Farm Japan | 15-16 wk | 280-340 | 177±11 | pMCAO (Tamura) | LDF | Neurol Res 2001;23:662-668 |
Cole DJ, et al. | SHR* | 16-20 wk | 375-425 | 126±9 / 131±7 | intraluminal suture |  | Can J Anaesth 2001;48:807-814 |
Yan Y, et al. | SHR/Charles River USA | NA | 270-300 | 133±8 | intraluminal suture |  | J Cereb Blood Flow Metab 2001;21:711-721 |
Rao VLR, et al. | SHR/Charles River USA | NA | 250-300 | 116±11 | intraluminal suture | LDF | J Cereb Blood Flow Metab 2001;21:945-954 |
Zhao Z, et al. | SHR/Charles River Canada | NA | 200-250 | 127±14 | dMCAO+ipsi-CCAO | LDF | Brain Res 2001;909:46-50 |
Marks L, et al. | SHRSP/Gla | 3-5 mo | 262±11 (SEM) | 123±9 (SEM) | dMCAO |  | Hypertension 2001;38:116-122 |
Gregersen R, et al. | SHR/Mollegaard | NA | 300-335 | NA | pMCAO | Â | Exp Brain Res 2001;138:384-392 |
Yao H, et al. | SHR/Kyushu | 5-7 mo | 350-438 | 187 (mean) | photothrombotic dMCAO | LDF | Brain Res Mol Brain Res 2001;91:112-118 |
Tejima E, et al. | SHR* | NA | 250-300 | 122±3 (SEM) | blood clots embolism | LDF | Stroke 2001;32:1336-1340 |
Lavie G, et al. | SHR/Tel Aviv | 13 wk | NA | 127±11 | dMCAO |  | Brain Res 2001;901:195-201 |
Furuya K, et al. | SHR/Charles River USA | 13-16 wk | NA | 140±7 | pMCAO (Tamura) |  | J Cereb Blood Flow Metab 2001;21:226-232 |
Holtz ML, et al. | SHR/Harlan | NA | 250-350 | 108±15 | dMCAO+ipsi-CCAO (Brint) |  | Brain Res 2001;898:49-60 |
Fredduzzi S, et al. | SHR/Charles River Italy | 12-14 wk | 250-330 | NA | pMCAO (Tamura) | Â | Neurosci Lett 2001;302:121-124 |
Rao VLR, et al. | SHR/Charles River USA | NA | 250-300 | NA | intraluminal suture | LDF | J Neurosci 2001;21:1876-1883 |
Negrin CD, et al. | SHRSP/Gla | 13 wk | NA | SBP=186±6 (SEM) | dMCAO |  | Hypertension 2001;37:391-397 |
Babu GN, et al. | SHR* | NA | 250-300 | NA | intraluminal suture | LDF | Neurosci Lett 2001;300:17-20 |
Legos JJ, et al. | SHR/Taconic Farms | NA | 300-350 | NA | dMCAO | Â | Brain Res 2001;892:70-77 |
Slivka AP, et al. | SHR* | NA | 240-400 | NA | dMCAO+ipsi-CCAO (Brint) | Â | Exp Neurol 2001;167:166-172 |
Barone FC, et al. | SHR/Taconic Farms | NA | 290-340 | 141±3 (SEM) | dMCAO |  | J Pharmacol Exp Ther 2001;296:312-321 |
Relton JK, et al. | SHR/Taconic Farms | NA | 250-350 | 168±15 (SEM) | intraluminal suture |  | Stroke 2001;32:199-205 |
Ooboshi H, et al. | SHR/Kyushu | 5-7 mo | 340-430 | 167±6 (SEM) | photothrombotic dMCAO | LDF | Stroke 2001;32:1043-1047 |
Dijkhuizen RM, et al. | SHR/Taconic Farms | NA | 300-350 | NA | blood clots embolism | LDF / MRI | J Cereb Blood Flow Metab 2001;21:964-971 |