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Table 1 Focal ischemia models in spontaneously hypertensive

From: Standards and pitfalls of focal ischemia models in spontaneously hypertensive rats: With a systematic review of recent articles

Author Substrains Age BW (g) MABP (mmHg) Methods of MCAO CBF References
Oyama N, et al. SHR/Charles River Jpan 10 wk NA 124±5 (SEM) intraluminal suture LDF J Neurosci Res 2010;88:2889-2898
Zhao X, et al. SHR/Harlan NA NA NA dMCAO+ipsi-CCAO (Brint) LDF Stroke 2010;41:363-367
Kranz A, et al. SHR/Charles River NA 250 NA pMCAO (Tamura)   Brain Res 2010;1315:128-136
Yang Y, et al. SHR* NA 300-320 NA intraluminal suture   J Neurochem 2010;112:134-149
Ito H, et al. SHR/Hos, Japan SLC 20-24 wk 346±33 209±13 photothrombotic dMCAO LDF J Cereb Blood Flow Metab 2010;30:343-351
Sun L, et al. SHR/Janvier France NA 300-350 120±11 blood clots embolism   J Cereb Blood Flow Metab 2010;30:1651-1660
Porritt MJ, et al. SHR/ARC Australia 16 mo 438±11 SBP=200-210 intraluminal suture   J Cereb Blood Flow Metab 2010;30:1520-1526
Yao H, et al. SHR/Izm, Japan SLC 5-7 mo 352±12 172±12 photothrombotic dMCAO/Re LDF Neurochem Res 2009;34:1999-2007
Yao H, et al. SHR/Izm, Japan SLC 5-7 mo NA 182 (mean) photothrombotic dMCAO/Re LDF J Cereb Blood Flow Metab 2009;29:565-574
McCabe C, et al. SHRSP/Gla 12-16 wk 220-390 93±4 intraluminal suture MRI Stroke 2009;40:3864-3868
Yan Y-P, et al. SHR/Charles River USA NA 270-320 NA intraluminal suture LDF Neurochem Int 2009;55:826-832
Ashioti M, et al. SHR/Charles River UK NA 200-250 NA dMCAO+ipsi-CCAO   BMC Neurosci 2009;10:82
Ishikawa E, et al. SHR/Kyushu 5-8 mo 360-440 154±11 photothrombotic dMCAO LDF J Neurol Sci 2009;285:78-84
Omura-Matsuoka E, et al. SHR/Charles River Jpan 10-15 wk 250-350 181±10 intraluminal suture LDF Hypertens Res 2009;32:548-553
Cao F, et al. SHRSP* 13-15 wk 250-300 NA dMCAO   Brain Res 2009;1272:52-61
Liu Y-P, et al. SHR/Charles River USA NA 290-310 130-140 intraluminal suture LDF J Cereb Blood Flow Metab 2009;29:780-791
Sasaki T, et al. SHR/Charles River Jpan NA 320±40 NA dMCAO+ipsi-CCAO (Brint) LDF Neurosci Lett 2009;449:61-65
Henning EC, et al. SHR/Charles River USA 3-4 mo 350±20 NA intraluminal suture   J Cereb Blood Flow Metab 2009;29:1229-1239
Dharap A, et al. SHR/Charles River USA NA 280-300 NA intraluminal suture   J Cereb Blood Flow Metab 2009;29:675-687
Ishibashi S, et al. SHR/Charles River USA 8 wk 180-220 NA dMCAO   J Cereb Blood Flow Metab 2009;29:606-620
Yamashita T, et al. SHR/Izm, Japan SLC 13 wk 250-280 117±29 intraluminal suture LDF J Cereb Blood Flow Metab 2009;29:715-725
Fujiwara N, et al. SHR/Charles River USA NA 303±8 183±6 blood clots embolism LDF BMC Neurosci 2009;10:79
Murata Y, et al. SHR/Charles River USA NA 283±8 184±5 blood clots embolism LDF Stroke 2008;39:3372-3377
Matsuzaki T, et al. SHR/Izm, Japan SLC 9 wk 240-290 126±17 intraluminal suture LDF Neurol Res 2008;30:531-535
Kozak W, et al. SHR/Charles River USA 12-13 wk 275-300 135±8 (telemetry) intraluminal suture LDF J Pharmacol Exp Ther 2008;326:773-782
Henning EC, et al. SHR/Charles River USA 3-4 mo 300-360 SBP=165-185 intraluminal suture   Stroke 2008;39:3405-3410
Park S-W, et al. SHR/Charles River USA NA 250-350 NA intraluminal suture LDF J Neurosurg 2007;107:593-599
Korde AS, et al. SHR/Harlan NA 250-350 94±3 dMCAO+ipsi-CCAO (Brint) LDF J Neurotrauma 2007;24:895-908
Kurasako T, et al. SHR/Harlan NA 220-300 101±12 dMCAO+ipsi-CCAO (Brint)   J Cereb Blood Flow Metab 2007;27:1919-1930
Jimenez-Altayo F, et al. SHR/Janvier Spain 13-15 wk 341±4 (SEM) SBP=204±2 (SEM) intraluminal suture   Am J Physiol Heart Circ Physiol 2007;293:H628-635
Tureyen K, et al. SHR/Charles River USA NA NA 135±9 intraluminal suture LDF J Neurochem 2007;101:41-56
Yao H, et al. SHRSP/Izm, Japan SLC 5 mo 315±30 241±22 photothrombotic dMCAO LDF Physiol Genomics 2007;30:69-73
Ashioti M, et al. SHR/Charles River UK NA 265±9 NA dMCAO+ipsi-CCAO   Brain Res 2007;1145:177-189
Mariucci G, et al. SHR/Charles River Italy 12-14 wk 250-330 NA pMCAO (Tamura)   Neurosci Lett 2007;415:77-80
Adibhatla RM, et al. SHR/Charles River USA NA 250-300 NA intraluminal suture   Brain Res 2007;1134:199-205
Leker RR, et al. SHR/Tel Aviv NA NA NA dMCAO   Stroke 2007;38:153-161
Kumai Y, et al. SHR/Kyushu 5-8 mo 340-435 164±2 (SEM) photothrombotic dMCAO LDF J Cereb Blood Flow Metab 2007;27:1152-1160
Yang Y, et al. SHR* NA 300-320 NA intraluminal suture   J Cereb Blood Flow Metab 2007;27:697-709
Yan Y-P, et al. SHR/Charles River USA NA 270-300 NA intraluminal suture LDF J Cereb Blood Flow Metab 2007;27:1213-1224
Takasawa M, et al. SHR/Charles River UK NA 295-305 NA dMCAO+ipsi-CCAO   J Cereb Blood Flow Metab 2007;27:679-689
Akaiwa K, et al. SHR* NA 250-290 144±5 intraluminal suture LDF Brain Res 2006;1122:47-55
Yan Y-P, et al. SHR/Charles River USA NA 250-300 130-140 intraluminal suture LDF Eur J Neurosci 2006;24:45-54
Lammer A, et al. SHR/Charles River Germany NA 250-300 NA pMCAO (Tamura)   Eur J Neurosci 2006;23:2824-2828
Bowen KK, et al. SHR/Charles River USA NA 280-320 NA intraluminal suture LDF Neurochem Int 2006;49:127-135
Komitova M, et al. SHR/Mollegaard 6 mo NA NA dMCAO   Exp Neurol 2006;199:113-121
Zhao L, et al. SHR/Charles River USA NA 250-350 118±12 dMCAO+ipsi-CCAO (Brint) AR / LDF J Cereb Blood Flow Metab 2006;26:1128-1140
Zhang B, et al. SHRSP* 16-18 wk NA 204±7 dMCAO   J Cereb Blood Flow Metab 2006;26:708-721
Furuya K, et al. SHR/Charles River Jpan NA 280-320 NA dMCAO+ipsi-CCAO (Brint) LDF J Neurosurg 2005;103:715-723
Kamiya T, et al. SHR/Harlan NA 225-325 161±13 dMCAO+ipsi-CCAO (Brint) AR Stroke 2005;36:2463-2467
Naylor M, et al. SHR/Charles River USA NA 280-320 NA intraluminal suture LDF Neurochem Int 2005;47:565-572
Adibhatla RM, et al. SHR* NA 250-275 NA intraluminal suture LDF Brain Res 2005;1058:193-197
Tsuji K, et al. SHR* NA 260-280 NA intraluminal suture LDF Stroke 2005;36:1954-1959
Gunther A, et al. SHR/Charles River Germany NA 250-330 NA pMCAO (Tamura)   Eur J Neurosci 2005;21:3189-3194
Vemuganti R SHR/Charles River USA NA 280-320 NA intraluminal suture LDF Neurochem Int 2005;47:136-142
Komitova M, et al. SHR/Mollegaard 6 mo 300-370 NA dMCAO   Eur J Neurosci 2005;21:2397-2405
Onoue S, et al. SHRSP* NA 280-320 NA dMCAO+ipsi-CCAO (Brint)   Brain Res Mol Brain Res 2005;134:189-197
Hobohm C, et al. SHR/Charles River Germany NA 250-330 NA pMCAO (Tamura)   J Neurosci Res 2005;80:539-548
Drummond JC, et al. SHR/Harlan 16-20 wk 375-425 131±9 intraluminal suture   Anesth Analg 2005;100:841-846
Ooboshi H, et al. SHR/Kyushu 5-8 mo 340-430 NA photothrombotic dMCAO LDF Circulation 2005;111:913-919
Takada J, et al. SHR/Kyushu 7-8 mo 352-450 153±10 photothrombotic dMCAO LDF Gene Ther 2005;12:487-493
Kumai Y, et al. SHR/Kyushu 5-10 mo 320-400 181±21 photothrombotic dMCAO LDF J Cereb Blood Flow Metab 2004;24:1359-1368
Carswell HV, et al. SHRSP/Gla, female 3-4 mo 179±11 140±15 dMCAO   J Cereb Blood Flow Metab 2004;24:298-304
Franke H, et al. SHR/Charles River Germany NA 250-330 NA pMCAO (Tamura)   J Neuropathol Exp Neurol 2004;63:686-699
Zhang B, et al. SHRSP* 12-13 wk 250-300 NA dMCAO   Neuroscience 2004;126:433-440
Dhodda VK, et al. SHR/Charles River USA NA 280-320 NA intraluminal suture LDF J Neurochem 2004;89:73-89
Nurmi A, et al. SHR/M&B A/S NA NA NA pMCAO   Stroke 2004;35:987-991
Vemuganti R, et al. SHR/Charles River USA NA 280-320 124±11 intraluminal suture LDF Stroke 2004;35:179-184
Ren Y, et al. SHR/Harlan NA 250-300 124±16 dMCAO+ipsi-CCAO (Brint)   J Cereb Blood Flow Metab 2004;24:42-53
Kumai Y, et al. SHR/Kyushu, female 5-7 mo 195-240 170±2 (SEM) photothrombotic dMCAO LDF Exp Neurol 2003;184:904-911
Babu GN, et al. SHR* NA 250-300 NA intraluminal suture LDF Neurochem Res 2003;28:1851-1857
Gautier S, et al. SHR/Elevage Janvier France NA 270-320 NA intraluminal suture   Stroke 2003;34:2975-2979
Asahi M, et al. SHR/Taconic Farms NA NA NA blood clots embolism LDF J Cereb Blood Flow Metab 2003;23:895–899.
Teichner A, et al. SHR* 13 wk NA NA dMCAO   Exp Neurol 2003;182:353-360
Sadanaga-Akiyoshi F, et al. SHR/Kyushu 5-7 mo 315-425 178±11/176±7 photothrombotic dMCAO LDF Neurochem Res 2003;28:1227-1234
Dahlqvist P, et al. SHR/Mollegaard 14-15 wk NA NA dMCAO   Neuroscience 2003;119:643-652
Pettigrew LC, et al. SHR/Harlan NA 250-300 98±17 dMCAO+ipsi-CCAO (Brint)   Neurol Res 2003;25:201-207
Yan Y, et al. SHR/Charles River USA NA 270-310 133±9 intraluminal suture   Brain Res 2003;961:22-31
Yamakawa H, et al. SHR/Taconic Farms 12 wk 300-500 SBP=156±4 dMCAO   J Cereb Blood Flow Metab 2003;23:371-380
Wiessner C, et al. SHR/Iffa Credo NA 220-300 NA dMCAO   J Cereb Blood Flow Metab 2003;23:154-165
Rao VLR, et al. SHR/Charles River USA NA 280-320 NA intraluminal suture LDF J Neurochem 2002;83:1072-1086
Aoki T, et al. SHR* NA NA 177±6 blood clots embolism LDF Stroke 2002;33:2711-2717
Leker RR, et al. SHR/Tel Aviv 13 wk NA 127±11 dMCAO LDF Exp Neurol 2002;176:355-363
Leker RR, et al. SHR/Tel Aviv 13 wk NA 127±5 dMCAO LDF Stroke 2002;33:1085-1092
Adibhatla RM, et al. SHR* NA NA NA intraluminal suture   Brain Res 2002;938:81-86
Sakakibara Y, et al. SHR/Charles River USA NA 280-350 116-128 intraluminal suture   Brain Res 2002;931:68-73
Sumii T, et al. SHR/Taconic Farms NA NA 185±6 (SEM) blood clots embolism LDF Stroke 2002;33:831-836
Jin J, et al. SHR/Hos, Japan SLC NA 130-160 NA pMCAO AR Pharmacology 2002;64:119-125
Higuchi T, et al. SHR/Charles River Jpan NA 261±32 88±12 dMCAO+ipsi-CCAO (Brint) LDF J Cereb Blood Flow Metab 2002;22:71-79
Ito T, et al. SHR/Taconic Farms 8 wk 190-240 SBP=153±6 (SEM) dMCAO   Stroke 2002;33:2297-2303
Wallace JA, et al. SHR* NA 280-320 NA intraluminal suture   J Cereb Blood Flow Metab 2002;22:1303-1310
Komitova M, et al. SHR/Mollegaard NA NA NA dMCAO   J Cereb Blood Flow Metab 2002;22:852-860
Johanson BB, et al. SHR/Mollegaard 3 mo NA NA dMCAO   J Cereb Blood Flow Metab 2002;22:89-96
Dijkhuizen RM, et al. SHR/Taconic Farms NA 300-350 NA blood clots embolism MRI Stroke 2002;33:2100-2104
Yao H, et al. SHR/Kyushu 5-7 mo 346-444 196 (mean) photothrombotic dMCAO/Re LDF Neuroreport 2002;13:1005-1008
Kitayama J, et al. SHR/Kyushu 5-8 mo 305-438 161±5 (SEM) photothrombotic dMCAO LDF Brain Res 2001;922:223-228
Furuya K, et al. SHR* NA NA NA dMCAO+ipsi-CCAO (Brint)   Stroke 2001;32:2665-2674
Takagi K, et al. SHR/Funabashi Farm Japan 15-16 wk 280-340 177±11 pMCAO (Tamura) LDF Neurol Res 2001;23:662-668
Cole DJ, et al. SHR* 16-20 wk 375-425 126±9 / 131±7 intraluminal suture   Can J Anaesth 2001;48:807-814
Yan Y, et al. SHR/Charles River USA NA 270-300 133±8 intraluminal suture   J Cereb Blood Flow Metab 2001;21:711-721
Rao VLR, et al. SHR/Charles River USA NA 250-300 116±11 intraluminal suture LDF J Cereb Blood Flow Metab 2001;21:945-954
Zhao Z, et al. SHR/Charles River Canada NA 200-250 127±14 dMCAO+ipsi-CCAO LDF Brain Res 2001;909:46-50
Marks L, et al. SHRSP/Gla 3-5 mo 262±11 (SEM) 123±9 (SEM) dMCAO   Hypertension 2001;38:116-122
Gregersen R, et al. SHR/Mollegaard NA 300-335 NA pMCAO   Exp Brain Res 2001;138:384-392
Yao H, et al. SHR/Kyushu 5-7 mo 350-438 187 (mean) photothrombotic dMCAO LDF Brain Res Mol Brain Res 2001;91:112-118
Tejima E, et al. SHR* NA 250-300 122±3 (SEM) blood clots embolism LDF Stroke 2001;32:1336-1340
Lavie G, et al. SHR/Tel Aviv 13 wk NA 127±11 dMCAO   Brain Res 2001;901:195-201
Furuya K, et al. SHR/Charles River USA 13-16 wk NA 140±7 pMCAO (Tamura)   J Cereb Blood Flow Metab 2001;21:226-232
Holtz ML, et al. SHR/Harlan NA 250-350 108±15 dMCAO+ipsi-CCAO (Brint)   Brain Res 2001;898:49-60
Fredduzzi S, et al. SHR/Charles River Italy 12-14 wk 250-330 NA pMCAO (Tamura)   Neurosci Lett 2001;302:121-124
Rao VLR, et al. SHR/Charles River USA NA 250-300 NA intraluminal suture LDF J Neurosci 2001;21:1876-1883
Negrin CD, et al. SHRSP/Gla 13 wk NA SBP=186±6 (SEM) dMCAO   Hypertension 2001;37:391-397
Babu GN, et al. SHR* NA 250-300 NA intraluminal suture LDF Neurosci Lett 2001;300:17-20
Legos JJ, et al. SHR/Taconic Farms NA 300-350 NA dMCAO   Brain Res 2001;892:70-77
Slivka AP, et al. SHR* NA 240-400 NA dMCAO+ipsi-CCAO (Brint)   Exp Neurol 2001;167:166-172
Barone FC, et al. SHR/Taconic Farms NA 290-340 141±3 (SEM) dMCAO   J Pharmacol Exp Ther 2001;296:312-321
Relton JK, et al. SHR/Taconic Farms NA 250-350 168±15 (SEM) intraluminal suture   Stroke 2001;32:199-205
Ooboshi H, et al. SHR/Kyushu 5-7 mo 340-430 167±6 (SEM) photothrombotic dMCAO LDF Stroke 2001;32:1043-1047
Dijkhuizen RM, et al. SHR/Taconic Farms NA 300-350 NA blood clots embolism LDF / MRI J Cereb Blood Flow Metab 2001;21:964-971
  1. *substrain unknown; NA, not available. Values are mean ± S.D. BW, body weight; MABP, mean arterial blood pressure;
  2. MCAO, middle cerebral artery occlusion; d, distal; p, proximal; ipsi, ispsilateral; Re, reperfusion;
  3. CBF, cerebral blood flow; LDF, laser Doppler flowmetry; AR, autoradiography; MIR, magnetic resonance imaging.