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Table 1 The baseline characteristics, laboratory findings and echocardiography results

From: Obesity suppresses circulating level and function of endothelial progenitor cells and heart function

Variables

Obesity (n = 8)

Control (n = 8)

P value*

Initial body weight (g)

25.7 ± 0.66

26.0 ± 0.72

0.448

Final body weight (g)

43.9 ± 1.55

34.4 ± 1.48

<0.0001

Heart weight (g)

0.19 ± 0.02

0.14 ± 0.01

<0.0001

Ratio of heart weight to tibial bone length

0.095 ± 0.002

0.070 ± 0.001

<0.001

Abdominal fat weight (g)

4.09 ± 0.65

1.66 ± 0.41

<0.0001

Total cholesterol (mg/dl)

232.8 ± 7.53

136.3 ± 11.8

<0.01

Initial fasting blood glucose level (mg/dl)†

103 ± 8.63

98.3 ± 9.0

0.657

Final fasting blood glucose level (mg/dl)†

307.5 ± 74.7

142.5 ± 18.3

<0.0001

Circulating level of endothelial progenitor cells

   

C-kit/CD31 (%)

   

Baseline (0 h)‡

1.15 ± 0.21

1.06 ± 0.40

0.636

18 hour§

2.60 ± 0.49

3.29 ± 0.50

0.025

Sca-1/KDR (%)

   

Baseline‡

0.85 ± 0.27

0.66 ± 0.21

0.169

18 hour§

1.05 ± 0.24

1.60 ± 0.22

0.042

CXCR4/CD34 (%)

   

Baseline (0 h)‡

0.38 ± 0.17

0.43 ± 0.27

0.745

18 hour§

0.68 ± 0.31

1.13 ± 0.36

0.033

Echocardiograph (baseline)

   

Inter-ventricular septum (mm)

0.82 ± 0.08

0.83 ± 0.09

0.360

Posterior wall (mm)

0.77 ± 0.11

0.76 ± 0.09

0.601

Left ventricular end-diastolic dimension (mm)

4.10 ± 0.10

3.93 ± 0.26

0.438

Left ventricular end-systolic dimension

2.71 ± 0.21

2.63 ± 0.23

0.588

Fractional shortening (%)

32.7 ± 1.98

34.4 ± 2.01

0.212

Left ventricular ejection fraction (%)

62.5 ± 2.43

64.0 ± 2.49

0.327

Echocardiograph (at end of study period)

   

Inter-ventricular septum (mm)

0.87 ± 0.06

0.86 ± 0.08

0.949

Posterior wall (mm)

0.79 ± 0.08

0.77 ± 0.03

0.686

Left ventricular end-diastolic dimension (mm)

4.46 ± 0.17b

4.18 ± 0.16a

0.031

Left ventricular end-systolic dimension

3.46 ± 0.48b

2.78 ± 0.13a

<0.001

Fractional shortening (%)

22.8 ± 1.15b

33.4 ± 0.85a

<0.001

Left ventricular ejection fraction (%)

46.0 ± 1.95b

62.7 ± 1.43a

<0.001

  1. Group 1 = obesity.
  2. Group 2 = normal control.
  3. * by t test.
  4. † value was observed after 12 fasting in the mice.
  5. ‡ blood sample was collected prior to critical limb ischemia procedure.
  6. § blood sample was collected at 18 h after critical limb ischemia procedure.
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Journal of Translational Medicine

ISSN: 1479-5876

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