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Table 1 The baseline characteristics, laboratory findings and echocardiography results

From: Obesity suppresses circulating level and function of endothelial progenitor cells and heart function

Variables Obesity (n = 8) Control (n = 8) P value*
Initial body weight (g) 25.7 ± 0.66 26.0 ± 0.72 0.448
Final body weight (g) 43.9 ± 1.55 34.4 ± 1.48 <0.0001
Heart weight (g) 0.19 ± 0.02 0.14 ± 0.01 <0.0001
Ratio of heart weight to tibial bone length 0.095 ± 0.002 0.070 ± 0.001 <0.001
Abdominal fat weight (g) 4.09 ± 0.65 1.66 ± 0.41 <0.0001
Total cholesterol (mg/dl) 232.8 ± 7.53 136.3 ± 11.8 <0.01
Initial fasting blood glucose level (mg/dl)† 103 ± 8.63 98.3 ± 9.0 0.657
Final fasting blood glucose level (mg/dl)† 307.5 ± 74.7 142.5 ± 18.3 <0.0001
Circulating level of endothelial progenitor cells    
C-kit/CD31 (%)    
Baseline (0 h)‡ 1.15 ± 0.21 1.06 ± 0.40 0.636
18 hour§ 2.60 ± 0.49 3.29 ± 0.50 0.025
Sca-1/KDR (%)    
Baseline‡ 0.85 ± 0.27 0.66 ± 0.21 0.169
18 hour§ 1.05 ± 0.24 1.60 ± 0.22 0.042
CXCR4/CD34 (%)    
Baseline (0 h)‡ 0.38 ± 0.17 0.43 ± 0.27 0.745
18 hour§ 0.68 ± 0.31 1.13 ± 0.36 0.033
Echocardiograph (baseline)    
Inter-ventricular septum (mm) 0.82 ± 0.08 0.83 ± 0.09 0.360
Posterior wall (mm) 0.77 ± 0.11 0.76 ± 0.09 0.601
Left ventricular end-diastolic dimension (mm) 4.10 ± 0.10 3.93 ± 0.26 0.438
Left ventricular end-systolic dimension 2.71 ± 0.21 2.63 ± 0.23 0.588
Fractional shortening (%) 32.7 ± 1.98 34.4 ± 2.01 0.212
Left ventricular ejection fraction (%) 62.5 ± 2.43 64.0 ± 2.49 0.327
Echocardiograph (at end of study period)    
Inter-ventricular septum (mm) 0.87 ± 0.06 0.86 ± 0.08 0.949
Posterior wall (mm) 0.79 ± 0.08 0.77 ± 0.03 0.686
Left ventricular end-diastolic dimension (mm) 4.46 ± 0.17b 4.18 ± 0.16a 0.031
Left ventricular end-systolic dimension 3.46 ± 0.48b 2.78 ± 0.13a <0.001
Fractional shortening (%) 22.8 ± 1.15b 33.4 ± 0.85a <0.001
Left ventricular ejection fraction (%) 46.0 ± 1.95b 62.7 ± 1.43a <0.001
  1. Group 1 = obesity.
  2. Group 2 = normal control.
  3. * by t test.
  4. † value was observed after 12 fasting in the mice.
  5. ‡ blood sample was collected prior to critical limb ischemia procedure.
  6. § blood sample was collected at 18 h after critical limb ischemia procedure.