Figure 4
Overall and disease-free survival curves assessed by Kaplan–Meier analysis according to HMGB1 expression and tumor size. (a) Overall survival. High expression of HMGB1 predicted poorer overall survival only for tumor >5 cm (group 3 VS group 4; p = 0.031); but not for tumor ≤5 cm (group 1 VS group 2; p = 0.101). (b) Disease-free survival. High expression of HMGB1 predict poor disease-free survival only for tumor >5 cm (group 3 VS group 4; p = 0.012); but not for tumor ≤5 cm (group 1 VS group 2; p = 0.087). Group 1, tumor ≤5 cm/ HMGB1 low expression (n = 49); group 2, tumor ≤5 cm/ HMGB1 high expression (n = 36); group 3, tumor >5 cm/ HMGB1 low expression (n = 43); group 4, tumor >5 cm/ HMGB1 high expression (n = 33).