Figure 4

Portal venous transplantation of ADMSC inhibits CCl ₄ induced hepatic fibrosis. Collagen fibers deposition was evaluated by A, H&E staining and B, Sirius red staining. C, Sirius red staining quantification. D, Hepatic hydroxyproline content was measured. Portal venous transplantation of ADMSC reversed fibrosis induced by CCl₄ injection, whereas tail vein transplantation of ADMSC failed to reduce the fibrosis significantly. *p < 0.05 versus 18 weeks of CCl₄ administration; #p < 0.05 between normal control and CCl₄ treatment (18w).