Table 3 Prognostic factors of septic patients at the emergency room
Non-survivors n = 11 | Survivors n = 56 | Crude OR (95% CI) | p value | Adjusted OR (95% CI) | p value | |
|---|---|---|---|---|---|---|
Age (y) (mean±SD) | 69.6±9.7 | 63.5±14.1 | 0.09 | |||
Male/Female | 8/3 | 36/20 | 0.68(0.16-2.84) | 0.74 | - | - |
Underlying diseases [n (%)] | ||||||
Diabetes mellitus | 5 (8) | 19 (28) | 0.62 (0.17-2.28) | 0.51 | - | - |
Hypertension | 5 (8) | 25 (37) | 0.97 (0.26-3.55) | 1.00 | - | - |
Liver diseases/alcoholism | 3 (5) | 8 (12) | 0.44 (0.97-2.04) | 0.37 | - | - |
Chronic obstructive pulmonary disease | 2 (3) | 6 (9) | 0.54 (0.09-3.11) | 0.61 | - | - |
Stroke | 3 (5) | 9 (13) | 0.51 (0.11-2.30) | 0.40 | - | - |
Coronary artery disease | 0 (0) | 8 (12) | 0.81 (0.72-0.92) | 0.34 | - | - |
Cancer | 4 (6) | 10 (15) | 0.38 (0.09-1.55) | 0.22 | - | - |
Connective tissue disease | 0 (0) | 1 (2) | 0.83 (0.75-0.93) | 1.00 | - | - |
Chronic renal disease | 0 (0) | 3 (5) | 0.83 (0.74-0.93) | 1.00 | - | - |
Glasgow coma score (mean±SD) | 13.1±2.4 | 12.7±3.7 | 0.76 | |||
Shock within 24 hours [n (%)] | 7 (11) | 37 (56) | 1.18 (0.30-4.54) | 1.00 | - | - |
Ventilator treatment within 24 hours [n (%)] | 8 (12) | 16 (24) | 0.15 (0.04-0.64) | 0.013 | - | - |
Disease severity index (mean±SD) | ||||||
Maximum 24-h APACHE II score | 20.9±3.8 | 18.9±6.9 | 0.36 | |||
Charlson Co-morbidity Index score | 4.2±2.8 | 2.9±2.8 | 0.18 | |||
Maximum 24-h SOFA score | 7.5±1.8 | 5.6±2.9 | 0.04 | |||
Laboratory data on admission | ||||||
Mean (SD) white blood cells (×10 9 /L) | 16.9 (12.6) | 15.7 (10.4) | 0.72 | |||
Mean (SD) Hemoglobin(mg/dL) | 12.7 (2.7) | 11.8 (2.1) | 0.24 | |||
Mean (SD) Platelet (×10 4 /L) | 114.0 (55.6) | 166.9 (98.3) | 0.09 | |||
Mean (SD) C-reactive protein (mg/dL) | 161.8 (107.0) | 195.7 (128.2) | 0.42 | |||
Mean (SD) Glucose (mg/dL) | 251.4 (218.8) | 167.5 (94.5) | 0.24 | |||
Mean (SD) Creatinine (mg/dL) | 1.7 (0.6) | 2.2 (1.6) | 0.36 | |||
Mean (SD) Lactate (mmol/L) | 62.5 (48.2) | 30.2 (13.8) | <0.001 | |||
Mean (SD) Procalcitonin(mg/dL) | 18.1 (16.4) | 34.0 (52.9) | 0.33 | |||
Mean (SD) B-type natriuretic peptide (pg/ml) | 776.3 (422.4) | 679.5 (523.9) | 0.79 | |||
Median (IQR) plasma nuclear DNA (ng/mL) | 2240 (1040–4760) | 400 (210–886) | <0.001 | 0.094 | 1.0 (0.99-1.0) | |
Median(IQR) plasma mitochondrial DNA (ng/mL) | 520 (218–846) | 121 (69–227) | <0.001 | 0.015 | 0.99 (0.99-0.999) |