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Table 3 Prognostic factors of septic patients at the emergency room

From: Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room

  Non-survivors n = 11 Survivors n = 56 Crude OR (95% CI) p value Adjusted OR (95% CI) p value
Age (y) (mean±SD) 69.6±9.7 63.5±14.1   0.09   
Male/Female 8/3 36/20 0.68(0.16-2.84) 0.74 - -
Underlying diseases [n (%)]       
Diabetes mellitus 5 (8) 19 (28) 0.62 (0.17-2.28) 0.51 - -
Hypertension 5 (8) 25 (37) 0.97 (0.26-3.55) 1.00 - -
Liver diseases/alcoholism 3 (5) 8 (12) 0.44 (0.97-2.04) 0.37 - -
Chronic obstructive pulmonary disease 2 (3) 6 (9) 0.54 (0.09-3.11) 0.61 - -
Stroke 3 (5) 9 (13) 0.51 (0.11-2.30) 0.40 - -
Coronary artery disease 0 (0) 8 (12) 0.81 (0.72-0.92) 0.34 - -
Cancer 4 (6) 10 (15) 0.38 (0.09-1.55) 0.22 - -
Connective tissue disease 0 (0) 1 (2) 0.83 (0.75-0.93) 1.00 - -
Chronic renal disease 0 (0) 3 (5) 0.83 (0.74-0.93) 1.00 - -
Glasgow coma score (mean±SD) 13.1±2.4 12.7±3.7   0.76   
Shock within 24 hours [n (%)] 7 (11) 37 (56) 1.18 (0.30-4.54) 1.00 - -
Ventilator treatment within 24 hours [n (%)] 8 (12) 16 (24) 0.15 (0.04-0.64) 0.013 - -
Disease severity index (mean±SD)       
Maximum 24-h APACHE II score 20.9±3.8 18.9±6.9   0.36   
Charlson Co-morbidity Index score 4.2±2.8 2.9±2.8   0.18   
Maximum 24-h SOFA score 7.5±1.8 5.6±2.9   0.04   
Laboratory data on admission       
Mean (SD) white blood cells (×10 9 /L) 16.9 (12.6) 15.7 (10.4)   0.72   
Mean (SD) Hemoglobin(mg/dL) 12.7 (2.7) 11.8 (2.1)   0.24   
Mean (SD) Platelet (×10 4 /L) 114.0 (55.6) 166.9 (98.3)   0.09   
Mean (SD) C-reactive protein (mg/dL) 161.8 (107.0) 195.7 (128.2)   0.42   
Mean (SD) Glucose (mg/dL) 251.4 (218.8) 167.5 (94.5)   0.24   
Mean (SD) Creatinine (mg/dL) 1.7 (0.6) 2.2 (1.6)   0.36   
Mean (SD) Lactate (mmol/L) 62.5 (48.2) 30.2 (13.8)   <0.001   
Mean (SD) Procalcitonin(mg/dL) 18.1 (16.4) 34.0 (52.9)   0.33   
Mean (SD) B-type natriuretic peptide (pg/ml) 776.3 (422.4) 679.5 (523.9)   0.79   
Median (IQR) plasma nuclear DNA (ng/mL) 2240 (1040–4760) 400 (210–886)   <0.001 0.094 1.0 (0.99-1.0)
Median(IQR) plasma mitochondrial DNA (ng/mL) 520 (218–846) 121 (69–227)   <0.001 0.015 0.99 (0.99-0.999)
  1. Abbreviations: SD, standard deviation; IQR, inter-quartile range; APACHE, Acute Physiology and Chronic Health Evaluation; SOFA, Sequential Organ Failure Assessment.