Table 4 Summary of studies involving the restoration of silenced miRNAs in CRC cell lines

let-7a-1

DLD-1

Ras

let-7a-1 precursor

Reduced cell viability, cell growth and colony formation

Akao, et al, 2006 [27]

SW480

c-myc

miR-34a

DLD-1

Sirt1

miR-34a mimic

Reduced cell growth

Akao, et al, 2011[75]

E2F3

Enhanced sensitivity to 5-FU

miR-34a

Rko

Axl

pre-miR-34a

Reduced migration & invasion

Mudduluru, et al, 2011 [76]

miR-133b

SW-620 HT-29

tyrosine kinase MET

miR-133b precursor

Reduces cell proliferation Increased apoptosis

Hu, et al, 2010 [81]

miR-135a/b

CLY

CM-1 cytotoxicity

miR-135a,

Increased sensitivity to anticancer agent

Li , et al, 2011[82]

HT-29

miR -135b mimics

miR-137

SW1116,

Cdc42

miR-137 mimic

Reduces cell proliferation , Cell cycle arrest

Liu, et al, 2011[83]

Lovo, Colo320

Inhibition of invasion

miR-143

SW480,

DNMT3A

miR-143 precursor

Reduces cell proliferation

Ng, et al, 2009 [79]

228

miR-143

DLD-1

miR-143 precursor

tumor-suppressive effect on xenografted tumors of DLD-1 human CRC cells

Nakagawa, et al, 2010 [80]

miR-145

LS174T

FLI1

miR-145 precursor

Reduces cell proliferation and colony formation

Zhang , et al, 2011 [84]

SW620 HCT116

miR145

HCT116

IRS-1

ds-oligos miR145

Reduces cell proliferation

Shi , et al, 2007 [85]

KO

miR-185

SW1116 Lovo

RhoA Cdc42

hsa-miR-185 mimic

Cell cycle arrest & growth suppression

Liu, et al, 2010 [86]

miR-192

RKO, LoVo, DLD1, SW620

TYMS

Pre-miR-192

Reduces cell proliferation

Boni, et al, 2010 [87]

miR-195

HT29 and LoVo

Bcl-2

miR-195 mimic

Reduces cellular viability Increased apoptosis

Liu, et al, 2010 [88]

Reduced colony formation

miR-196a

SW480

HoxA7, HoxB8, HoxC8 HoxD8

miR-196a mimics

Reduced migration , invasion

Schimanski, et al, 2009 [89]

Increased cellular adhesion

Increased sensitivity to platin derived anticancer agents

miR-199a

Rko

Axl

pre-miR-199a

Reduced migration , invasion

Mudduluru, et al, 2011[76]

miR 200c

CLY

CM-1 cytotoxicity

miR 200c

Low chemosenstivity with high miR-200c

Li, et al, [82]

HT-29

mimics

miR-215

RKO, LoVo, DLD1, SW620

TYMS

pre-miR-215

Reduces cell proliferation

Boni, et al, 2010 [87]

miR-491

DLD-1

Bcl-XL

miR-491 precursor

Reduces cell proliferation

Nakano, et al, 2010 [90]

Increased apoptosis