MicroRNA manipulation in colorectal cancer cells: from laboratory to clinical application

Table 3 Summary of in vitro effects of antisense oligonucleotides and locked nucleic acid based oncogenic miRNA manipulation in colorectal cell lines

miRNA	Cell line	Target	Method	Reported effects of miRNA manipulation	References
antisense oligonucleotides
miR-20a	SW480	BNIP2	anti–miR-20a	Increased sensitivity to fluorouracil, oxaliplatin, and teniposide	Chai, et al, 2011[61]
	SW620
miR-21	RKO	Pdcd4	anti-miR-21	Reduced intravasation and distal metastasis	Asangani, et al, 2008[62]
miR-31	HCT-116		anti-miR-31	Reduced migration and increased invasion	Wang , et al, 2010[63]
				Reduced proliferation only with combined 5-FU
miR-95	HCT-116 LoVo	SNX1	anti–miR-95	Reduces cell proliferation	Huang , et al, 2011[64]
		EGFR
miR-675	CaCO2 HCT116	RB	anti-miR-675	Reduced cell growth and colony transformation	Tsang , et al, 2010 [65]
	HT-29 SW480
Locked nucleic acid (LNA)
miR-21	SW480	hMSH2 hMSH6	LNA anti-miR-21	Increased sensitivity to 5-FU	Valeri, et al, 2010 [67]
	HCT-116
	RKO

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