Table 2 Summary of sensitivity and specificity of different diagnostic circulating miRNAs
From: MicroRNA manipulation in colorectal cancer cells: from laboratory to clinical application
Tissue type | Studies | Participants | Target MiRNAs | Diagnostic accuracy | |
|---|---|---|---|---|---|
| Â | Â | Â | Â | Sensitivity% | Specificity% |
Whole Plasma | Pu, et al, 2010 [51] | CRC (n = 103) | miR-221 | 86 | 41 |
|  |  | Controls (n = 37) |  |  |  |
Plasma | Cheng , et al, 2011 [52] | CRC I-IV (n = 102) | miR-141 | 66.7 | 80.8 |
|  |  | Controls (n = 48) |  |  |  |
RNA | Ng, et al, 2009 [53] | CRC (n = 90) | miR-17-3p | 64 | 70 |
|  |  | Controls (n = 40) | miR-92 | 89 | 70 |
|  | Huang, et al, 2010 [54] | CRC (n = 100) | miR-29 | 69 | 89.1 |
|  |  | Adenomas* (n = 37) |  | 62.2* | 84.7* |
| Â | Â | Â | miR-92a | 84 | 71 |
|  |  | Controls (n = 59) |  | 64.9* | 81.4* |