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Figure 5 | Journal of Translational Medicine

Figure 5

From: MicroRNA manipulation in colorectal cancer cells: from laboratory to clinical application

Figure 5

Figure demonstrates the mechanism of Knockdown of oncomiRs. The downregulation of tumour suppressor mRNAs can be reversed by a) transcriptional inhibition of genes transcribing miRNAs of oncogenic potential b) competitive inhibition of mature miRNAs with antisense oligonucleotides c) mRNA mask constructs causing competitive inhibition to miR/RISC d) sponge constructs mimicking target mRNAs e) induction of SNPs in RISC complex.

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