Figure 3
From: MicroRNA manipulation in colorectal cancer cells: from laboratory to clinical application
Figure illustrates the mechanism of biogenesis and function of OncomiRNAs. Amplification, translocation, mutation or pleomorphism in miRNA transcribing genes results in over production of pri-miRNA and pre-miRNAs in the nucleous. Further processing by the DICER results in higher levels of mature miRNAs in the cytoplasm. These overexpressed miRNAs target tumour suppressor mRNAs in the cytoplasm and lead to the downregulation of mRNAs.