Table 1 Summary of Tumorgraft Development
From: Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue
Location | Tumor type | # Models | Success | Failure | Success (%) |
|---|---|---|---|---|---|
Breast | Breast Cancer | 55 | 3 | 52 | 5 |
| Â | Total | 55 | 3 | 52 | 5 |
Endocrine | Neuroendocrine Tumor | 3 | 1 | 2 | 33 |
| Â | Papillary Thyroid Carcinoma | 2 | 0 | 2 | 0 |
| Â | Total | 5 | 1 | 4 | 20 |
Gastrointestinal | Cecal Adenocarcinoma | 1 | 1 | 0 | 100 |
| Â | Cholangiocarcinoma | 1 | 0 | 1 | 0 |
| Â | Colorectal Cancer | 17 | 8 | 9 | 47 |
| Â | Esophageal Adenocarcinoma | 5 | 2 | 3 | 40 |
| Â | Gallbladder Carcinoma | 1 | 0 | 1 | 0 |
| Â | Gastric Carcinoma | 3 | 1 | 2 | 33 |
| Â | Hepatoblastoma | 1 | 0 | 1 | 0 |
| Â | Pancreatic Cancer | 6 | 3 | 3 | 50 |
| Â | Small Bowel Cancer | 2 | 0 | 2 | 0 |
| Â | Total | 37 | 15 | 22 | 41 |
Genitourinary | Bladder Carcinoma | 1 | 0 | 1 | 0 |
| Â | Clear Cell Sarcoma | 1 | 0 | 1 | 0 |
| Â | Prostate Adenocarcinoma | 1 | 0 | 1 | 0 |
| Â | Renal Cell Carcinoma | 4 | 0 | 4 | 0 |
| Â | Urachal Adenocarcinoma | 1 | 1 | 0 | 100 |
| Â | Wilms Tumor | 1 | 1 | 0 | 100 |
| Â | Total | 9 | 2 | 7 | 22 |
Gynecologic | Ovarian Carcinoma | 2 | 0 | 2 | 0 |
| Â | Total | 2 | 0 | 2 | 0 |
Head and Neck | Head and Neck Cancer | 2 | 2 | 0 | 100 |
| Â | Nasopharyngeal Cancer | 1 | 0 | 1 | 0 |
| Â | Squamous Cell Carcinoma of the mouth | 1 | 0 | 1 | 0 |
| Â | Total | 4 | 2 | 2 | 50 |
Leukemia | Acute Lymphoblastic Leukemia | 1 | 0 | 1 | 0 |
| Â | Total | 1 | 0 | 1 | 0 |
Lung | Squamous Cell Carcinoma of the lung | 5 | 0 | 5 | 0 |
| Â | Lung Adenocarcinoma | 4 | 1 | 3 | 25 |
| Â | Small Cell Lung Cancer | 1 | 0 | 1 | 0 |
| Â | NSCLC | 13 | 5 | 8 | 38 |
| Â | Total | 23 | 6 | 17 | 26 |
Lymphoma | Burkitts Lymphoma | 1 | 0 | 1 | 0 |
| Â | Follicular Lymphoma | 3 | 0 | 3 | 0 |
| Â | Hodgkins Lymphoma | 1 | 0 | 1 | 0 |
| Â | Lymphoangioma | 1 | 0 | 1 | 0 |
| Â | Lymphoma | 6 | 0 | 6 | 0 |
| Â | Total | 12 | 0 | 12 | 0 |
Musculoskeletal | Desmoid Tumor | 1 | 0 | 1 | 0 |
| Â | Ewings Sarcoma | 3 | 2 | 1 | 67 |
| Â | Hemangiopericytoma | 1 | 0 | 1 | 0 |
| Â | Leiomysarcoma | 1 | 0 | 1 | 0 |
| Â | Osteosarcoma | 3 | 3 | 0 | 100 |
| Â | Rhabdomyosarcoma | 3 | 1 | 2 | 33 |
| Â | Synovial Sarcoma | 1 | 1 | 0 | 100 |
| Â | Total | 13 | 7 | 6 | 54 |
Neurologic | Neuroblastoma | 1 | 0 | 1 | 0 |
| Â | Total | 1 | 0 | 1 | 0 |
Skin | Melanoma | 18 | 11 | 7 | 61 |
| Â | Merkel Cell Carcinoma | 2 | 2 | 0 | 100 |
| Â | Total | 20 | 13 | 7 | 65 |
Final Total | 182 | 49 | 133 | 27 | |