Figure 6
From: Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue
Immune response pathway map enriched with genes down-regulated in the tumorgraft forming patient tumors. The MetaCore™ pathway analysis suite (GeneGo-Thomson Reuters, St. Joseph, MI) identified a pathway map for an immune response involving integrins in NK cell cytotoxicity that was enriched for several ligands down-regulated in tumors that did not form tumorgrafts (Target cell denotes tumor cells).