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Figure 4 | Journal of Translational Medicine

Figure 4

From: Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

Figure 4

Enrichment of canonical pathway maps in genes up and downregulated in tumorgraft forming tumors compared to non-tumorgraft forming tumors. Ontology enrichment analysis was performed using the MetaCore™ pathway analysis suite (GeneGo-Thomson Reuters, St. Joseph, MI). A) The top ten canonical pathway maps enriched in the genes up-regulated (n = 491) in the tumors that formed tumorgrafts included cell signalling and cell cycle-related pathways. B) Eight of top ten canonical pathway maps enriched in the genes down-regulated (n = 691) in the tumorgrafts that formed tumorgrafts were immune-related pathways.

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