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Figure 3 | Journal of Translational Medicine

Figure 3

From: Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

Figure 3

Enrichment of canonical pathway maps in genes downregulated in tumorgrafts compared to their donor tumors. A) Scatter plot of expression of gene probes (25,806) graphically depicting the up-regulated (red circle) and down-regulated (green circle) 2-fold or greater (t-test, p ≤ 0.05) in tumorgrafts relative to the originating patient tumors. B) Ontology enrichment analysis was performed using the MetaCore™ pathway analysis suite (GeneGo-Thomson Reuters, St. Joseph, MI). Eight of the top ten canonical pathways enriched in the genes down-regulated in the tumorgrafts, relative to the originating patient tumors, were immune-related, consistent with immunodeficient status of the murine host.

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