Figure 3From: Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissueEnrichment of canonical pathway maps in genes downregulated in tumorgrafts compared to their donor tumors. A) Scatter plot of expression of gene probes (25,806) graphically depicting the up-regulated (red circle) and down-regulated (green circle) 2-fold or greater (t-test, p ≤ 0.05) in tumorgrafts relative to the originating patient tumors. B) Ontology enrichment analysis was performed using the MetaCore™ pathway analysis suite (GeneGo-Thomson Reuters, St. Joseph, MI). Eight of the top ten canonical pathways enriched in the genes down-regulated in the tumorgrafts, relative to the originating patient tumors, were immune-related, consistent with immunodeficient status of the murine host.Back to article page