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Figure 3 | Journal of Translational Medicine

Figure 3

From: Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

Figure 3

Transient pharmacological immunosuppression fails to enhance rAAV5-mediated gene transfer to the liver in macaques. A) Sequential follow-up of PBGD activity in homogenates from liver samples taken at the indicated time points. Normal range was defined as means ± 2 standard deviation of a separate group of four non-injected female macaques. B) Analyses of human PBGD mRNA content by quantitative RT-PCR in liver homogenates from necropsies taken at sacrifice (week 25). C) Immunohistochemistry detection of hepatocytes overexpressing PBGD on formalin-fixed and paraffin-embedded sections from liver biopsies obtained from the indicated animals at sacrifice. Data corresponding to necropsy samples (week 25) are expressed as median ± standard deviation of eight different lobes in each macaque.

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