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Figure 2 | Journal of Translational Medicine

Figure 2

From: Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates

Figure 2

Administration of second rAAV5 vector of the same serotype cannot achieve transgene expression even under immunosuppression of macaques with the five-drug regimen. A) Representative microphotographs of liver sections from the necropsy material of the indicated animals upon immunostaining with an anti-eGFP polyclonal antibody. The positive control animal (NHP004) received only a rAAV-egfp injection as indicated in Figure 1. B) mRNA analysis by RT-PCR corresponding to specific egfp mRNA expression in liver of colour-coded animals. Data are expressed as median ± standard deviation of eight different lobes in each macaque. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus naïve non-human primate.

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