Figure 7From: Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell linesPossible involvement of AEG-1 in a p53 independent apoptotic pathway. After DNA-damage the MRN complex is recruited to the DNA break. AEG-1 is activated after DNA damage by an unknown mechanism, leading to NF-κB activation. The active p65 subunit of NF-κB is required for p73 dependent Noxa gene expression, leading to apoptosis.Back to article page