Table 2 Gene targets of the most common described human cancer-associated miRNAs

MiR-21

CRC, PC, RCC, GBM, BrC, NSCLC, BCL, PTC, HCC, HNSCC, ESCC, GC, CML, CCC, MM, OC, M, LC, PDA

PDCD4, TIMP3, RhoB, Spry1, PTEN, TM1, CDK2AP1, ANP32A, SMARCA4, ANKRD46, THRB, Cdc25A, BMPRRII, LRRFIP1, BTG2, MARCKS, TPM1

MiR-155

NSCLC, SCLC, HCC, BrC, M, CCC, HL, PDA, RCC, GBM, PTC, CML, CRC, SPA, AML, NPC, CLL

FOXO3A, SOX6, SATB1, SKI, Wee1, SOCS1, SHIP1, S/EBPβ, IFN-γRα, AGTR1, FGF7, ZNF537, ZIC3, IKBKE, RhoA, BACH1, ZIC3, HIVEP2, CEBPB, ZNF652, ARID2, SMAD5, TP53INP1

MiR-145

BrC, CRC, ESCC, NSCLC, PC, BCL, OC, GC, BlC, NPC, HCC

c-Myc, ERK5, FSCN1, SMAD2/3, IGF-1R, FLI1, DFF45, mucin 1, MYO6, CBFB, PPP3CA, CLINT1, ICP4, RTKN

MiR-221

BrC, PC, CRC, M, GBM, ALL, HCC, PTC, PDA, GC, CML, NSCLC, AML, OC

DVL2, KIT, CDKN1B, Bmf, p27, HOXB5, CDKN1C/p57, CDKN1B/p27, MMP1, SOD2, TIMP3, Dicer1, ERα, ARHI, PUMA, p27Kip1, p57

MiR-222

Let-7a

M, HL, nHL, CRC, SLC, NSCLC, GC, HNSCC, ESCC, OC, CLL, HCC

PRDM-1, STAT3, Caspase-3, Integrin β3, PRDM1/blimp-1

MiR-16

LC, OC, NPC, GC, PC, BrC, HCC, MM, CLL, HL

VEGFR2, FGFR1, Zyxin, Cyclin E1, Bmi-1, BRCA-1, BCL2

MiR-200

BrC, PDA, GC, HNSCC, M, OC, PC

FN1, MSN, NTRK2, LEPR, ARHGAP19, ZEB1/2, Flt1/VEGFR1, FAP-1, FOG2, ERRFI-1

MiR-205

M, BrC, PC, ESCC, HNSCC

Runx2, E2F1, ErbB3, Zeb1

MiR-31

PTC, CRC, BrC, LC, GC, HCC

LATS2, WAVE3, SATB2, ITGA5, RDX, RhoA, FIH

MiR-126

CRC, GC, BrC, SCLC, AML, NSCLC, HCC

SLC7A5, SOX2, PLAC1, VEGFA, PIK3R2, Crk, EGFL7, p85beta

MiR-210

PDA, RCC, BrC, PC, GBM, NSCLC, OC, GC, HNSCC

FGFRL1, SDHD, MNT

MiR-9

GBM, PC, nHL, EC, OC

CAMTA1, PDGFR-β, CDX2, PRDM-1, E-cadherin, NF-kappaB1

MiR-141

PC, EC, CRC, HNSCC, LC, BrC, ESCC, OC, RCC

SIP1, YAP1

MiR-122

HCC, RCC

Bcl-w, ADAM17