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Table 6 Multivariate Cox regression analysis A) for HER2/TOP2A co-amplification, B) for HER2/TOP2A mRNA expression, C) for HER2/TopoIIa protein expression and D) for all combined HER2/TOP2A parameters, adjusted for significant clinicopathological parameters in terms of DFS and OS

From: HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy

  

Disease-free survival

Overall survival

  

HR

95% C.I.

Wald's p

HR

95% C.I.

Wald's p

A)

E-CMF vs E-T-CMF

1.26

0.85-1.88

0.25

1.67

1.03-1.72

0.038

 

Nodal involvement (≥ 4 vs 0-3)

3.53

1.82-6.85

< 0.001

2.96

2.96

0.004

 

Hormone receptor status (pos. vs neg.)

0.48

0.31-0.77

0.002

0.40

0.24-0.68

0.018

 

Ki-67 (high vs low)

1.97

1.06-3.65

0.031

2.77

1.19-6.46

0.018

 

HER2&TOP2A gene (both ampl. vs all other)

0.12

0.02-0.88

0.037

0.16

0.02-1.14

0.067

B)

E-CMF vs E-T-CMF

1.16

0.77-1.75

0.47

1.56

0.95-2.57

0.079

 

Nodal involvement (≥ 4 vs 0-3)

2.67

1.44-4.93

0.002

2.07

1.05-4.09

0.035

 

Hormone receptor status (pos. vs neg.)

0.57

0.36-0.91

0.018

0.48

0.28-0.83

0.008

 

Ki67 (high vs low)

1.92

0.98-3.77

0.057

3.40

1.22-9.48

0.019

 

HER2&TOP2A mRNA (high vs low)

2.30

1.39-3.81

0.001

2.48

1.41-4.36

0.002

C)

E-CMF vs E-T-CMF

1.18

0.80-1.74

0.39

1.62

1.02-2.57

0.042

 

Nodal involvement (≥ 4 vs 0-3)

3.00

1.64-5.49

< 0.001

2.43

1.25-4.73

0.009

 

Hormone receptor status (pos. vs neg.)

0.64

0.41-0.99

0.047

0.51

0.31-0.85

0.009

 

Ki67 (high vs low)

1.68

0.93-3.05

0.086

2.27

1.03-5.00

0.041

 

HER2&TopoIIa IHC (both pos. vs all other)

1.77

1.04-3.05

0.034

1.58

0.86-2.91

0.14

D)

E-CMF vs E-T-CMF

1.13

0.73-1.75

0.59

1.53

0.89-2.26

0.12

 

Nodal involvement (≥ 4 vs 0-3)

3.62

1.78-7.34

< 0.001

2.87

1.29-6.40

0.010

 

Hormone receptor status (pos. vs neg.)

0.51

0.31-0.84

0.009

0.45

0.25-0.81

0.008

 

Ki67 (high vs low)

2.05

0.99-4.21

0.051

4.35

1.34-14.18

0.015

 

HER2&TOP2A gene (both ampl. vs all other)

0.13

0.02-0.96

0.046

0.23

0.03-1.74

0.15

 

HER2&TOP2A mRNA (high vs low)

2.41

1.31-4.42

0.005

2.83

1.42-5.63

0.003

 

HER2&TopoIIa IHC (both pos. vs all other)

1.36

0.68-2.70

0.38

0.92

0.42-2.18

0.92

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Journal of Translational Medicine

ISSN: 1479-5876

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