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Table 6 Multivariate Cox regression analysis A) for HER2/TOP2A co-amplification, B) for HER2/TOP2A mRNA expression, C) for HER2/TopoIIa protein expression and D) for all combined HER2/TOP2A parameters, adjusted for significant clinicopathological parameters in terms of DFS and OS

From: HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy

   Disease-free survival Overall survival
   HR 95% C.I. Wald's p HR 95% C.I. Wald's p
A) E-CMF vs E-T-CMF 1.26 0.85-1.88 0.25 1.67 1.03-1.72 0.038
  Nodal involvement (≥ 4 vs 0-3) 3.53 1.82-6.85 < 0.001 2.96 2.96 0.004
  Hormone receptor status (pos. vs neg.) 0.48 0.31-0.77 0.002 0.40 0.24-0.68 0.018
  Ki-67 (high vs low) 1.97 1.06-3.65 0.031 2.77 1.19-6.46 0.018
  HER2&TOP2A gene (both ampl. vs all other) 0.12 0.02-0.88 0.037 0.16 0.02-1.14 0.067
B) E-CMF vs E-T-CMF 1.16 0.77-1.75 0.47 1.56 0.95-2.57 0.079
  Nodal involvement (≥ 4 vs 0-3) 2.67 1.44-4.93 0.002 2.07 1.05-4.09 0.035
  Hormone receptor status (pos. vs neg.) 0.57 0.36-0.91 0.018 0.48 0.28-0.83 0.008
  Ki67 (high vs low) 1.92 0.98-3.77 0.057 3.40 1.22-9.48 0.019
  HER2&TOP2A mRNA (high vs low) 2.30 1.39-3.81 0.001 2.48 1.41-4.36 0.002
C) E-CMF vs E-T-CMF 1.18 0.80-1.74 0.39 1.62 1.02-2.57 0.042
  Nodal involvement (≥ 4 vs 0-3) 3.00 1.64-5.49 < 0.001 2.43 1.25-4.73 0.009
  Hormone receptor status (pos. vs neg.) 0.64 0.41-0.99 0.047 0.51 0.31-0.85 0.009
  Ki67 (high vs low) 1.68 0.93-3.05 0.086 2.27 1.03-5.00 0.041
  HER2&TopoIIa IHC (both pos. vs all other) 1.77 1.04-3.05 0.034 1.58 0.86-2.91 0.14
D) E-CMF vs E-T-CMF 1.13 0.73-1.75 0.59 1.53 0.89-2.26 0.12
  Nodal involvement (≥ 4 vs 0-3) 3.62 1.78-7.34 < 0.001 2.87 1.29-6.40 0.010
  Hormone receptor status (pos. vs neg.) 0.51 0.31-0.84 0.009 0.45 0.25-0.81 0.008
  Ki67 (high vs low) 2.05 0.99-4.21 0.051 4.35 1.34-14.18 0.015
  HER2&TOP2A gene (both ampl. vs all other) 0.13 0.02-0.96 0.046 0.23 0.03-1.74 0.15
  HER2&TOP2A mRNA (high vs low) 2.41 1.31-4.42 0.005 2.83 1.42-5.63 0.003
  HER2&TopoIIa IHC (both pos. vs all other) 1.36 0.68-2.70 0.38 0.92 0.42-2.18 0.92